IntegenLLC is a Florida, US based company having a proprietary technology - ICP (Interphase Chromosome Profiling) for applications in chromosome profiling, specifically genetics.
ICP Concept: Individual chromosomes are studied in their uncondensed state in an interphase nucleus using a panel of FISH probes that target DNA sequences in an equidistant fashion along the entire length of the chromosome. Using only three fluorophores for each chromosome arm, one can “walk” along the whole chromosome in a sequential manner using standard fluorescence microscopy. The resolution obtained with the ICP approach is approximately 600 bands, sufficient to detect numerical changes and all clinically relevant structural abnormalities from POC and oncology samples. Some targets are read once while others are read twice with two different fluorophores and the resulting “banding pattern” is distinct with each target molecularly different from its neighboring target or any other target on that chromosome.