Multiplex Ligation Dependent Probe Amplification (MLPA)
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR based technique which enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be processed simultaneously with result within 24 hours. Over 400 assays targeting various genetic diseases are available.DSS Imagetech Pvt Ltd is the sole authorised distributor for MRC Holland in India.
DSS offers assays from the MRC Holland portfolio. Customers are trained on assays and the software and provided with all possible technical support.
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SALSA® digital Multiplex Ligation-dependent Probe Amplification (digitalMLPA) is a multiplex PCR followed by Illumina sequencing-based amplicon quantification, for the detection of copy number variations (CNV) and specific point mutations.
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Methylation-Specific (MS)-MLPA® is a variant of the MLPA technique, the gold standard in copy number determination. With MS-MLPA, it is possible to semi-quantitatively profile methylation for multiple targets simultaneously.
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MLPA Assays are useful in finding out those who have Lung Disorders
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MLPA can be used for the detection of deletions or duplications of certain genes involved in cardiovascular diseases.
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MLPA Assays are useful in finding out those who have hereditary blood disorders.
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MLPA Assays are useful in finding out those who have Skeletal & Connective Tissue Disorders
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MLPA Assays are useful in tumor profiling for blood cancer, solid tumors as well as general tumor profiling
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The SALSA digitalMLPAProbemix D006-A1 Multiple Myeloma is a research use only (RUO) assay for the detection of deletions, gains or amplifications of genes and chromosomal regions mentioned in Table 2 that are recurrently altered in multiple myeloma, such as 1p, 1q, 13q and 17p, as well as for the detection of BRAF p.V600E point mutation.
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The SALSA digitalMLPA Probemix D007-A1 Acute lymphocytic leukemia is a research-use-only (RUO) assay for the detection of deletions, gains or amplifications in 52 specific target genes and three chromosomal regions (5q, iAMP21 and PAR1), which are related to acute lymphoblastic leukemia (ALL).
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SALSA® Melt Assays are designed for the fast and reliable screening of a small number of targets in a large number of samples.
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