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Metaphase Arresting Solution

Metaphase Arresting Solution
MAS (Metaphase Arresting Solution) is a ProCell Cytogenetics Reagent that is a highly refined solution of colchicine/vinblastine sulphate in PBS, used to increase the percentage of metaphase cells for chromosomal studies.
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Product Details

ProCell Cytogenetics Reagents product range was developed in collaboration with scientists working in a clinical oncology cytogenetics unit. The ProCell range is designed to improve culture failure rates, mitotic index, metaphase spreading, banding resolution and overall quality of bone marrow, lymphoma, solid tumour, blood, CVS and Amniocentesis samples for cytogenetic analysis.

Metaphase Arresting Solution is a highly refined solution of colchicine/vinblastine sulphate in PBS, used to increase the percentage of metaphase cells for chromosomal studies. The product is designed to be more effective than colchicine alone for bone marrows, difficult tumours and other problematic tissues with low mitotic indexes, and where colchicine/colcemid appears to be ineffective..

Metaphase Arresting Solution has been found to be useful for sensitive cultures where cells lift off when colchicine is added. It is gentler than colchicine so cells do not have such an adverse reaction.

Metaphase arresting solution is a gentle alternative to colchicine/colcemid and contains colchicine and vinblastine sulphate. This means that it is less toxic to cells because the concentration of colchicine is reduced whilst the extrablocking activity of vinblastine sulphate means that it is extremely effective. Rounded-up cells in culture are much less to likely to lift off when treated with MAS and MAS may be used as a direct replacement for colchicine/colcemid without major alteration to existing laboratory protocols.
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