MINFLUX

The MINFLUX platform presents an unparalleled spectrum of imaging capabilities, enabling the resolution of molecular-scale structures in all three spatial dimensions. This unparalleled resolution capability, coupled with unprecedented imaging speed, unveils hitherto unobservable sample intricacies. The MINFLUX stands as the preeminent fluorescence microscope worldwide, demonstrating the highest level of power and performance in its class.

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Features & Benefits

When employing a conventional microscope stand, MINFLUX is capable of achieving three-dimensional resolution ranging from 1 to 3 nanometers (nm), enabling the widespread applicability of fluorescence microscopy at the molecular scale.
MINFLUX facilitates the precise localization of individual fluorescent molecules within biological specimens while employing minimal photon fluxes, achieving localization precision of less than 1 nm.
Technological advancements, such as the synchronization of electro-optical and galvanometric beam steering, coupled with sample position stabilization that attains sub-nanometer precision in relation to the microscope stand, guarantee the real-time localization of individually activated fluorophores with nanometer-level accuracy.

Product Details

In MINFLUX, the localization of single emitters is achieved through the utilization of a toroidal excitation beam featuring a central intensity minimum, which systematically traverses a hexagonal probing sequence centered around the estimated molecule position. The emissions obtained from each probing position yield crucial data for pinpointing the precise molecule location. The refinement of molecule localization accuracy is enhanced through successive iterations employing increasingly smaller probing patterns during scanning.