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Clonality in Lymphoprolifertive Processes

Clonality in Lymphoprolifertive Processes

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  1. IgH

    IgH

    This kit allows detection of clonality in B cell lymphoproliferative processes by amplification of rearranged VDJ segments in the hypervariable region of the immunoglobulin heavy chain (IgH), using multiple primers that hybridise with conserved regions in the genes.

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  2. IgK - IgL

    This kit allows detection of clonality in B cell lymphoproliferative processes by amplification of rearranged V-J and Kde (Vk-Kde and RSS-Kde) rearranged segments of IgK as well as V-J rearranged segment of IgL, using multiple primers that hybridise with conserved regions in the genes.

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  3. TCR Beta

    This kit allows detection of clonality in T-originating lymphoproliferative processes, using the amplification of rearranged VJ segments of the TCRgamma gene.

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  4. TCR Gamma

    The TCRgamma gene is a preferential target for the analysis of T cloning because rearrangement occurs early in lymphoid T development, probably just after TCRdelta, in both TCRgd and TCRab precursors.

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