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SALSA MLPA Reagent Kits for Cardiovascular

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SALSA MLPA Reagent Kits for Cardiovascular
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.
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Features & Benefits

  • Cardiovascular Disease Detectionr
  • Simultaneous Detection of copy number, methylation and known point mutation
  • Low Input - Requires only 50 ng of DNA
  • Reproducible - High concordance with other techniques
  • Time Efficient - Results available within 24 hrs.
  • High Throughput - Can detect up to 60 sequences in 96  DNA samples, in one reactions
  • Cost Effective

Product Details

MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.


Components provided per SALSA MLPA Reagent Kit  



  • SALSA MLPA Buffer (yellow cap)

  • SALSA Ligase-65 (green cap)

  • Ligase Buffer A (transparent cap)

  • Ligase Buffer B (white cap)

  • SALSA PCR Primer Mix (brown cap)

  • SALSA Polymerase (orange cap) 


MLPA has the following solutions for Cardiovascular Disorders:
























































































































PRODUCT NAME APPLICATION REGION
P065-Marfan-1 Marfan syndrome FBN1 15q21.1, TGFBR2 3p22
P066-Marfan-2 Marfan syndrome FBN1 15q21.1
P093-HHT/PPH1 Hemorrhagic telangiectasia, hereditary (HHT), Primary pulmonary hypertension (PPH1) ENG 9q34.11, ACVRL1 12q13.3, BMPR2 2q33.1-2
P100-MYBPC3 Hypertrophic cardiomyopathy, familial MYBPC3 11p11.2
P108-SCN5A Brugada / long QT SCN5A 3p22
P114-Long-QT Congenital long QT syndrome (LQT) KCNQ1 11p15.5, KCNH2 7q35
P130-CCM mix-1 Cerebral Cavernous Malformations (CCM) CCM 7q21
P131-CCM mix-2 Cerebral Cavernous Malformations (CCM) CCM 7q21
P148-TGFBR1-TGFBR2 Aortic aneurysm syndrome TGFBR1 9q22, TGFBR2 3p22
P168-ARVC-PKP2 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C) DSP 6p24, PKP2 12q11.21
P180-Limb-2 Limb malformations, heart SALL1 16q12, SALL4 20q13, TBX5 12q24
P184-JAG1 Alagille Syndrome (AGS) JAG1 20p12.2
P196-TNNT2-BAG3 Hypertrophic cardiomyopathy familial, Dilated cardiomyopathy TNNT2 1q32; BAG3 10q25
P234-GATA3 - GATA4 Cardiac septal defects GATA4 8p23, GATA3 10p15
P311-CHD Congenital Heart Disease (CHD) GATA4 8p23, NKX2-5 5q35, TBX5 12q24, BMP4 14q22, CRELD1 3p25
P313-CREBBP Rubinstein–Taybi syndrome (RSTS) CREBBP 16p13.3
P333-EP300 Rubinstein–Taybi syndrome (RSTS) EP300; 22q13.2
P350-CLCN1-KCNJ2 Myotonia congenita, Thomsen’s disease, Becker’s disease, Andersen-Tawil syndrome CLCN1, KCNJ2
P409-RASA1 capillary malformations, Parkes Weber syndrome RASA1 5q14.3
P418-MYH7 Hypertrophic cardiomyopathy MYH7 14q11.2
P434-Heterotaxy Heterotaxy syndrome ZIC3 Xq26.3, CFC1 2q21.1, ACVR2B 3p22.2, NODAL 10q22.1
P456-EVC EVC2 Ellis-van Creveld syndrome 4p16.2
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