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SALSA MLPA Reagent Kits for Hereditary Blood Disorders

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SALSA MLPA Reagent Kits for Hereditary Blood Disorders
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.
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Features & Benefits

  • Hereditary Blood Disorder Detection
  • Simultaneous Detection of copy number, methylation and known point mutation
  • Low Input - Requires only 50 ng of DNA
  • Reproducible - High concordance with other techniques
  • Time Efficient - Results available within 24 hrs.
  • High Throughput - Can detect up to 60 sequences in 96  DNA samples, in one reactions
  • Cost Effective

Product Details

MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.


Components provided per SALSA MLPA Reagent Kit  



  • SALSA MLPA Buffer (yellow cap)

  • SALSA Ligase-65 (green cap)

  • Ligase Buffer A (transparent cap)

  • Ligase Buffer B (white cap)

  • SALSA PCR Primer Mix (brown cap)

  • SALSA Polymerase (orange cap) 


MLPA has the following solutions for Hereditary Blood Disorders:





























































































































PRODUCT NAME APPLICATION REGION
P011-VWF mix 1 Von Willebrand Disease (vWD) vWF 12p13
P012-VWF mix 2 Von Willebrand Disease (vWD) vWF 12p13
P013-ATRX Alpha-Thalassemia/Mental Retardation ATRX ; Xq13
P031-FANCA mix 1 Fanconi Anemia (FA) FANCA 16q24.3
P032-FANCA mix 2 Fanconi Anemia (FA) FANCA 16q24.3
P057-FANCD2-PALB2 Fanconi anemia (FA) FANCD2. 3p25.3, PALB2 16p12
P102-HBB Thalassemia, beta-zero HBB 11p15.5
P112-PROS1 PROS1 deficiency PROS1 3q11.2
P140-HBACE Thalassemias, Alpha HBA 16p
P178-F8 Haemophilia A, x-linked F8 gene, Xq28
P203-PKLR Haemolytic Anaemia, hereditary non-spherocytic PKLR 1q22
P207-F9 Factor IX deficiency, Christmas disease F9 Xq27.1
P212-DBA Diamond-Blackfan anemia (DBA) RPL11, RPL5, RPL35A, RPS26, RPS17 and RPS19
P227-SerpinC1 Antithrombin (III) deficiency SerpinC1 1q25.1
P236-ARMD mix-1basic research Age-related macular degeneration (ARMD) CFH, CFHR3, CFHR1, CFHR2, 1q23
P240-BRIP1/CHEK1 Hereditary predisposition to Cancer BRIP1 17q22, CHEK1 11q22
P257-TERT-DKC1 Dyskeratosis congenita (DC) DKC1 Xq28
P260-PALB2-RAD50-RAD51C-RAD51D Fanconi Anemia 5q31, 16p12, 17q12, 17q22
P265-PROC Protein C deficiency (PROC) PROC 2q14.3
P296-aHUS Hemolytic uremic syndrome, atypical (aHUS) CFI 4q25
P432-MYH9 Macrothrombocytopenia 22q12.3
P440-F10 + F11 Factor X deficiency; Rosenthal syndrome 4q35.2 & 13q34
P469-F5new Factor V deficiency F5 1q24.2
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