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SALSA MLPA Reagent Kits for Immunological

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SALSA MLPA Reagent Kits for Immunological
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.
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Features & Benefits

  • Detection of Immunological Disorders
  • Simultaneous Detection of copy number, methylation and known point mutation
  • Low Input - Requires only 50 ng of DNA
  • Reproducible - High concordance with other techniques
  • Time Efficient - Results available within 24 hrs.
  • High Throughput - Can detect up to 60 sequences in 96  DNA samples, in one reactions
  • Cost Effective

Product Details

MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.


Components provided per SALSA MLPA Reagent Kit  



  • SALSA MLPA Buffer (yellow cap)

  • SALSA Ligase-65 (green cap)

  • Ligase Buffer A (transparent cap)

  • Ligase Buffer B (white cap)

  • SALSA PCR Primer Mix (brown cap)

  • SALSA Polymerase (orange cap) 


MLPA has the following solutions for Immunological:































































































PRODUCT NAME APPLICATION REGION
P028-FHL Familial lymphohistiocytosis (HLH) UNC13D 17q25.1, PRF1 10q22.1, STX11 6q24.2
P041-ATM-1 Ataxia-Telangiectasia (AT) ATM 11q23
P042-ATM-2 Ataxia-Telangiectasia (AT) ATM 11q23
P094-MEFV Mediterranean fever, familial (MEFV) MEFV 16p13.3
P110-FCGR mix 1basic research FCGR genes 1q23.3 FCGR genes 1q23.3
P111-FCGR mix 2basic research FCGR genes 1q23.3 FCGR genes 1q23.3
P205-SH2D1A-XIAP-ITK Lymphoproliferative syndrome SH2D1A and XIAP (Xq25); ITK (5q33)
P236-ARMD mix-1basic research Age-related macular degeneration (ARMD) CFH, CFHR3, CFHR1, CFHR2, 1q23
P243-SERPING1 - F12 Hereditary angioedema (HAE) SERPING1 11q12.1; F12 5q35.3
P247-Chemokine-2basic research Chemokines CXCR4, CX3CR1, CCR5, CCR2, CD4, CD209
P296-aHUS Hemolytic uremic syndrome, atypical (aHUS) CFI 4q25
P368-DCLRE1C SCID and Omenn syndrome 10p13; DCLRE1C
P385-DOCK8 HIES 9p24.3
P386-DOCK8 STAT3 HIES 17q21.2, 9p24.3
P430-PLCG2 Cold-induced urticaria 16q23
P438-HLA Celiac Disease, HLA-DQ2.5 HLA-DQ8 HLA-DQ2.2 6p21.32
P454-CGD Chronic Granulomatous Disease Xp21.1; 1q25.3; 16q24.3; 22q13.1
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