SALSA MLPA Reagent Kits for Intellectual Disability

MRC HOLLAND SALSA MLPA Reagent Kits for Intellectual Disability in India

More Views

SALSA MLPA Reagent Kits for Intellectual Disability
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.
Read More
Add to Shortlist

Features & Benefits

  • Detection of Intellectual Disability Disorders
  • Simultaneous Detection of copy number, methylation and known point mutation
  • Low Input - Requires only 50 ng of DNA
  • Reproducible - High concordance with other techniques
  • Time Efficient - Results available within 24 hrs.
  • High Throughput - Can detect up to 60 sequences in 96  DNA samples, in one reactions
  • Cost Effective

Product Details

MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.

Components provided per SALSA MLPA Reagent Kit  

  • SALSA MLPA Buffer (yellow cap)

  • SALSA Ligase-65 (green cap)

  • Ligase Buffer A (transparent cap)

  • Ligase Buffer B (white cap)

  • SALSA PCR Primer Mix (brown cap)

  • SALSA Polymerase (orange cap) 

MLPA has the following solutions for Intellectual Disability:

ME028-PWS/ASimprovedPrader Willi syndrome (PWS), Angelman syndrome (AS)PWS/AS region (15q11-13), MKRN3, MAGEL2, NDN, SNRPN, UBE3A, ATP10A, GABRB3, OCA2
ME029-FMR1/AFF2Fragile XFMR1, AFF2
ME032-UPD7-UPD14Uniparental disomy6q24, 7p12, 7q32 and 14q32
P013-ATRXAlpha-Thalassemia/Mental RetardationATRX ; Xq13
P015-MECP2RETT syndromeMECP2, Xq28
P026-SotosSotos syndromeNSD1, 5q35
P029-WBSWilliams-Beuren syndromeWBS criticial region 7q11.23
P036-Subtelomeres Mix 1CESubtelomeric testingAll subtelomeres
P046-TSC2Tuberous SclerosisTSC2 16p13.3
P049-SLC6A8 - ABCD1Creatine transporter, x-linkedSLC6A8, Xq28
P061-LissencephalyimprovedLissencephalyLIS1, DCX, POMT1, POMGnT1, FLNA
P064-MR-1Mental Retardation; 1p-deletion, Williams, Smith-Magenis, Miller-Dieker, DiGeorge, Prader-Willi, Alagille, Saethre-Chotzen, SotosVarious
P069-Subtelomeres Mix 2ACESubtelomeric testingAll subtelomeres
P070-Subtelomeres Mix 2BCESubtelomeric testingAll subtelomeres
P075-TCF4-FOXG1Pitt-Hopkins syndrome, Congential variant of Rett syndromeTCF4, FOXG1
P095-AneuploidyCEDown syndrome, Edwards syndrome, Patau syndromeChr. 13, 18, 21, X, Y
P096-MR-2Mental retardation, Wolf-Hirschhorn, Cri du Chat, Langer-Giedon, WAGR, Rubinstein-Taybi, Down, KabukiVarious
P103-DPYDDihydropyrimidine dehydrogenase (DPYD) deficiencyDPYD 1p22
P106-MRXMental retardation, x-linked (XLMR)Chromosome X
P122-NF1-areaNeurofibromatosisNF1 17q11.2
P124-TSC1Tuberous SclerosisTSC1 9q34
P141-NIPBL-1Cornelia de Lange syndrome (CDLS)NIPBL 5p13.2
P142-NIPBL-2Cornelia de Lange syndrome (CDLS)NIPBL 5q13.1
P147-1p361p36 deletion syndrome1p36
P187-HPEHoloprosencephaly (HPE)PTCH, SHH, ZIC2, SIX3, TGIF TMEM1, FBXW11
P188-22q13Phelan-Mcdermid syndrome, Telomeric monosomy 22q13.322q13.3, SHANK3, ACR, RABL2B
P189-CDKL5Rett syndrome, atypicalCDKL5 Xp22, NTNG1 1p13.3, ARX Xp21.3
P208-Human Telomere-6Subtelomeric testing2p, 3p, 6p, 8p
P230-Human Telomere-7Subtelomeric testing9p, 10p, 11p, 12p
P233-MID1OPITZ syndromeMID1 Xp22
P245-Microdeletion-1Microdeletion syndromesVarious
P249-Human Telomere-8Subtelomeric testing17p, 18p, 19p, 20p
P250-DiGeorgeCEDiGeorge syndrome22q11
P259-RPS6KA3Coffin-Lowry Syndrome (CLS)RPS6KA3, PQBP1.
P267-Dandy-WalkerDandy-Walker Malformation (DWM)ZIC1, ZIC4 3p2, VLDLR 9p24
P275-MAPT-GRNAlzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration, progressive supranuclear palsyMAPT 17q21
P277-Human Telomere-10Subtelomeric testing5q, 6q, 7q, 8q
P286-Human Telomere-11Subtelomeric testing9q, 10q, 11q, 12q
P290-PrenatalPrenatal microdeletion testingVarious
P291-Human Telomere-12Subtelomeric testing13q, 14q, 15q, 16q
P297-Microdeletion-2Microdeletion syndromesVarious
P313-CREBBPRubinstein–Taybi syndrome (RSTS)CREBBP 16p13.3
P320-Human Telomere-13Subtelomeric testing17q, 18q, 19q, 20q.
P321-VPS13B mix 1Cohen syndromeVPS13B 8q22
P322-VPS13B mix 2Cohen syndromeVPS13B 8q22
P325-OCA2oculocutaneous albinismOCA2 15q12; TYR 11q14.3
P326-LARGEWalker-Warburg SyndromeLARGE, FKTN, POMT2
P330-PCDH19Epilepsy (EFMR)PCDH19
P333-EP300Rubinstein–Taybi syndrome (RSTS)EP300; 22q13.2
P337-TSC2Tuberous sclerosisTSC2 gene, 16p13.3
P339-SHANK3Autism Spectrum DisorderSHANK3 22q13.33
P343-Autism-1Autism15q11-13: UBE3A, GABRB3; 16p11; SHANK3 22q13
P355-MicrocephalyPrimary MicrocephalyMCPH1, ASPM, CDK5RAP2, CENPJ, STIL
P356-Chromosome 22qSubtelomeric testing22q11, 22q13
P358-Human Telomere-15Subtelomeric testing4p, 5p telomeres and 13q,14q centromere regions
P365-Human Telomere-14Subtelomeric testing7p, 15q-cen, 16p, 21q-cen, 21q
P369-Smith-MagenisSmith-Magenis syndrome17p11.2
P371-Microdeletion-5Microdeletion follow-up2p16, Langer Giedion, 9q22, WAGR, 15q24, 17q21
P372-Microdeletion-6Microdeletion follow-upSotos, DiGeorge, Rubinstein-Taybi, NF1
P373-Microdeletion-7Microdeletion follow-up1p36, 3q29, Wolf-Hirschhorn, Cri du Chat, Phelan-McDermid
P374-Microdeletion-8Microdeletion follow-up: 7q11, PWS/AS, Miller-Dieker, Smith-Magenis, RETT7q11, PWS/AS, Miller-Dieker, Smith-Magenis, RETT
P379-NRXN1Pitt-Hopkins-like syndrome 2NRXN1
P388-AGSAicardi-Goutieres SyndromeRNASEH2A, B & C genes, TREX1, SAMHD1
P389-MLL2Kabuki syndromeMLL2 gene
P395-MEF2C-FOXG1mental retardationMEF2C 5q14.3, FOXG1 14q12
P398-CASKX-linked mental retardation and MICPCHCASK
P410-GRIN2A GRIN2Bepilepsy, mental retardation16p13.2 GRIN2A, 12p13.1 GRIN2B
P426-CystinuriaCystinuriaSLC3A1, 2p12 and SLC7A9
P433-ARID1A-ARID1BNeuroblastoma, ovarian cancer + various other tumour types + mental retardationARID1A, ARID1B
P443-KANSL1KANSL1 copy number17q21.31
P445-KDM6AKabuki Syndrome Type 2 (KS2)Xp11.3
P457-DHCR7Smith–Lemli–Opitz syndrome11q13
Read More