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SALSA MLPA Reagent Kits for Intellectual Disability

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SALSA MLPA Reagent Kits for Intellectual Disability
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.
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Features & Benefits

  • Detection of Intellectual Disability Disorders
  • Simultaneous Detection of copy number, methylation and known point mutation
  • Low Input - Requires only 50 ng of DNA
  • Reproducible - High concordance with other techniques
  • Time Efficient - Results available within 24 hrs.
  • High Throughput - Can detect up to 60 sequences in 96  DNA samples, in one reactions
  • Cost Effective

Product Details

MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.


Components provided per SALSA MLPA Reagent Kit  



  • SALSA MLPA Buffer (yellow cap)

  • SALSA Ligase-65 (green cap)

  • Ligase Buffer A (transparent cap)

  • Ligase Buffer B (white cap)

  • SALSA PCR Primer Mix (brown cap)

  • SALSA Polymerase (orange cap) 


MLPA has the following solutions for Intellectual Disability:























































































































































































































































































































































































PRODUCT NAME APPLICATION REGION
ME028-PWS/ASimproved Prader Willi syndrome (PWS), Angelman syndrome (AS) PWS/AS region (15q11-13), MKRN3, MAGEL2, NDN, SNRPN, UBE3A, ATP10A, GABRB3, OCA2
ME029-FMR1/AFF2 Fragile X FMR1, AFF2
ME032-UPD7-UPD14 Uniparental disomy 6q24, 7p12, 7q32 and 14q32
P013-ATRX Alpha-Thalassemia/Mental Retardation ATRX ; Xq13
P015-MECP2 RETT syndrome MECP2, Xq28
P026-Sotos Sotos syndrome NSD1, 5q35
P029-WBS Williams-Beuren syndrome WBS criticial region 7q11.23
P036-Subtelomeres Mix 1CE Subtelomeric testing All subtelomeres
P046-TSC2 Tuberous Sclerosis TSC2 16p13.3
P049-SLC6A8 - ABCD1 Creatine transporter, x-linked SLC6A8, Xq28
P061-Lissencephalyimproved Lissencephaly LIS1, DCX, POMT1, POMGnT1, FLNA
P064-MR-1 Mental Retardation; 1p-deletion, Williams, Smith-Magenis, Miller-Dieker, DiGeorge, Prader-Willi, Alagille, Saethre-Chotzen, Sotos Various
P069-Subtelomeres Mix 2ACE Subtelomeric testing All subtelomeres
P070-Subtelomeres Mix 2BCE Subtelomeric testing All subtelomeres
P075-TCF4-FOXG1 Pitt-Hopkins syndrome, Congential variant of Rett syndrome TCF4, FOXG1
P095-AneuploidyCE Down syndrome, Edwards syndrome, Patau syndrome Chr. 13, 18, 21, X, Y
P096-MR-2 Mental retardation, Wolf-Hirschhorn, Cri du Chat, Langer-Giedon, WAGR, Rubinstein-Taybi, Down, Kabuki Various
P103-DPYD Dihydropyrimidine dehydrogenase (DPYD) deficiency DPYD 1p22
P106-MRX Mental retardation, x-linked (XLMR) Chromosome X
P122-NF1-area Neurofibromatosis NF1 17q11.2
P124-TSC1 Tuberous Sclerosis TSC1 9q34
P141-NIPBL-1 Cornelia de Lange syndrome (CDLS) NIPBL 5p13.2
P142-NIPBL-2 Cornelia de Lange syndrome (CDLS) NIPBL 5q13.1
P147-1p36 1p36 deletion syndrome 1p36
P187-HPE Holoprosencephaly (HPE) PTCH, SHH, ZIC2, SIX3, TGIF TMEM1, FBXW11
P188-22q13 Phelan-Mcdermid syndrome, Telomeric monosomy 22q13.3 22q13.3, SHANK3, ACR, RABL2B
P189-CDKL5 Rett syndrome, atypical CDKL5 Xp22, NTNG1 1p13.3, ARX Xp21.3
P208-Human Telomere-6 Subtelomeric testing 2p, 3p, 6p, 8p
P230-Human Telomere-7 Subtelomeric testing 9p, 10p, 11p, 12p
P233-MID1 OPITZ syndrome MID1 Xp22
P245-Microdeletion-1 Microdeletion syndromes Various
P249-Human Telomere-8 Subtelomeric testing 17p, 18p, 19p, 20p
P250-DiGeorgeCE DiGeorge syndrome 22q11
P259-RPS6KA3 Coffin-Lowry Syndrome (CLS) RPS6KA3, PQBP1.
P267-Dandy-Walker Dandy-Walker Malformation (DWM) ZIC1, ZIC4 3p2, VLDLR 9p24
P275-MAPT-GRN Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration, progressive supranuclear palsy MAPT 17q21
P277-Human Telomere-10 Subtelomeric testing 5q, 6q, 7q, 8q
P286-Human Telomere-11 Subtelomeric testing 9q, 10q, 11q, 12q
P290-Prenatal Prenatal microdeletion testing Various
P291-Human Telomere-12 Subtelomeric testing 13q, 14q, 15q, 16q
P297-Microdeletion-2 Microdeletion syndromes Various
P313-CREBBP Rubinstein–Taybi syndrome (RSTS) CREBBP 16p13.3
P320-Human Telomere-13 Subtelomeric testing 17q, 18q, 19q, 20q.
P321-VPS13B mix 1 Cohen syndrome VPS13B 8q22
P322-VPS13B mix 2 Cohen syndrome VPS13B 8q22
P325-OCA2 oculocutaneous albinism OCA2 15q12; TYR 11q14.3
P326-LARGE Walker-Warburg Syndrome LARGE, FKTN, POMT2
P330-PCDH19 Epilepsy (EFMR) PCDH19
P333-EP300 Rubinstein–Taybi syndrome (RSTS) EP300; 22q13.2
P336-UBE3A Angelman UBE3A, MTHFR, GABRB3
P337-TSC2 Tuberous sclerosis TSC2 gene, 16p13.3
P339-SHANK3 Autism Spectrum Disorder SHANK3 22q13.33
P343-Autism-1 Autism 15q11-13: UBE3A, GABRB3; 16p11; SHANK3 22q13
P355-Microcephaly Primary Microcephaly MCPH1, ASPM, CDK5RAP2, CENPJ, STIL
P356-Chromosome 22q Subtelomeric testing 22q11, 22q13
P358-Human Telomere-15 Subtelomeric testing 4p, 5p telomeres and 13q,14q centromere regions
P365-Human Telomere-14 Subtelomeric testing 7p, 15q-cen, 16p, 21q-cen, 21q
P369-Smith-Magenis Smith-Magenis syndrome 17p11.2
P371-Microdeletion-5 Microdeletion follow-up 2p16, Langer Giedion, 9q22, WAGR, 15q24, 17q21
P372-Microdeletion-6 Microdeletion follow-up Sotos, DiGeorge, Rubinstein-Taybi, NF1
P373-Microdeletion-7 Microdeletion follow-up 1p36, 3q29, Wolf-Hirschhorn, Cri du Chat, Phelan-McDermid
P374-Microdeletion-8 Microdeletion follow-up: 7q11, PWS/AS, Miller-Dieker, Smith-Magenis, RETT 7q11, PWS/AS, Miller-Dieker, Smith-Magenis, RETT
P379-NRXN1 Pitt-Hopkins-like syndrome 2 NRXN1
P388-AGS Aicardi-Goutieres Syndrome RNASEH2A, B & C genes, TREX1, SAMHD1
P389-MLL2 Kabuki syndrome MLL2 gene
P395-MEF2C-FOXG1 mental retardation MEF2C 5q14.3, FOXG1 14q12
P398-CASK X-linked mental retardation and MICPCH CASK
P410-GRIN2A GRIN2B epilepsy, mental retardation 16p13.2 GRIN2A, 12p13.1 GRIN2B
P426-Cystinuria Cystinuria SLC3A1, 2p12 and SLC7A9
P433-ARID1A-ARID1B Neuroblastoma, ovarian cancer + various other tumour types + mental retardation ARID1A, ARID1B
P443-KANSL1 KANSL1 copy number 17q21.31
P445-KDM6A Kabuki Syndrome Type 2 (KS2) Xp11.3
P457-DHCR7 Smith–Lemli–Opitz syndrome 11q13
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