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SALSA MLPA Reagent Kits for Kidney

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SALSA MLPA Reagent Kits for Kidney
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.
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Features & Benefits

  • Kidney Disorder Detection
  • Simultaneous Detection of copy number, methylation and known point mutation
  • Low Input - Requires only 50 ng of DNA
  • Reproducible - High concordance with other techniques
  • Time Efficient - Results available within 24 hrs.
  • High Throughput - Can detect up to 60 sequences in 96  DNA samples, in one reactions
  • Cost Effective

Product Details

MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.


Components provided per SALSA MLPA Reagent Kit  



  • SALSA MLPA Buffer (yellow cap)

  • SALSA Ligase-65 (green cap)

  • Ligase Buffer A (transparent cap)

  • Ligase Buffer B (white cap)

  • SALSA PCR Primer Mix (brown cap)

  • SALSA Polymerase (orange cap) 


MLPA has the following solutions for Kidney:



















































































































PRODUCT NAME APPLICATION REGION
P118-WT1 Wilms tumours, WAGR, Denys-Drash, Frasier syndrome. WT1 11p13
P136-Gitelman Gitelman syndrome SLC12A3 16q13
P153-EYA1 Branchio-oto-renal dysplasia syndrome (BOR) EYA1 8q13.3.
P191-Alport-mix1 Alport syndrome, Hereditary Nephritis COL4A5 Xq22
P192-Alport-mix2 Alport syndrome, Hereditary Nephritis COL4A5 Xq22
P234-GATA3 - GATA4 Cardiac septal defects GATA4 8p23, GATA3 10p15
P236-ARMD mix-1basic research Age-related macular degeneration (ARMD) CFH, CFHR3, CFHR1, CFHR2, 1q23
P256-FLCN Birt-Hogg-Dube syndrome FLCN 17p11, Smith-Magenis syndrome region
P266-CLCNKB Bartter syndrome type 3 CLCNKB 1p36.13
P296-aHUS Hemolytic uremic syndrome, atypical (aHUS) CFI 4q25
P305-AGXT Primary hyperoxaluria, type 1 (PH1) & type 2 (PH2) AGXT, GRHPR
P341-PKHD1 mix 1 Autosomal Recessive Polycystic Kidney Disease (ARPKD) PKHD1
P342-PKHD1 mix 2 Autosomal Recessive Polycystic Kidney Disease (ARPKD) PKHD1
P351-PKD1 Autosomal Dominant Polycystic Kidney Disease (ADPKD) PKD1
P352-PKD1-PKD2 Autosomal Dominant Polycystic Kidney Disease (ADPKD) PKD1, PKD2
P380-Wilms' tumour Wilms' tumour various
P387-NPHP1 Nephronophthisis 1 NPHP1 2q13
P426-Cystinuria Cystinuria SLC3A1, 2p12 and SLC7A9
P439-COL4A3 Alport Syndrome 02q36.3
P444-COL4A4 Alport Syndrome 2q36.3
P473-CTNSnew (Nephropathic) Cystinosis 17p13.2
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