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SALSA MLPA Reagent Kits for Microdeletion

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SALSA MLPA Reagent Kits for Microdeletion
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.
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Features & Benefits

  • Detection of Microdeletion
  • Simultaneous Detection of copy number, methylation and known point mutation
  • Low Input - Requires only 50 ng of DNA
  • Reproducible - High concordance with other techniques
  • Time Efficient - Results available within 24 hrs.
  • High Throughput - Can detect up to 60 sequences in 96  DNA samples, in one reactions
  • Cost Effective

Product Details

MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.


Components provided per SALSA MLPA Reagent Kit  



  • SALSA MLPA Buffer (yellow cap)

  • SALSA Ligase-65 (green cap)

  • Ligase Buffer A (transparent cap)

  • Ligase Buffer B (white cap)

  • SALSA PCR Primer Mix (brown cap)

  • SALSA Polymerase (orange cap) 


MLPA has the following solutions for Microdeletion:













































































































































































































































































































































































PRODUCT NAME APPLICATION  REGION
ME028-PWS/ASimproved Prader Willi syndrome (PWS), Angelman syndrome (AS) PWS/AS region (15q11-13), MKRN3, MAGEL2, NDN, SNRPN, UBE3A, ATP10A, GABRB3, OCA2
ME029-FMR1/AFF2 Fragile X FMR1, AFF2
ME030-BWS/RSS Beckwith-Wiedemann Syndrome (BWS), Russell-Silver Syndrome (RSS) 11p15 region, H19, IGF2, CDKN1C, KCNQ1
P015-MECP2 RETT syndrome MECP2, Xq28
P018-SHOXCE Idiopathic growth retardation SHOX-Xp22
P022 -PLP1 Pelizaeus-Merzbacher disease (PMD) PLP1 Xq22
P026-Sotos Sotos syndrome NSD1, 5q35
P029-WBS Williams-Beuren syndrome WBS criticial region 7q11.23
P033-CMT1CE Charcot-Marie Tooth disease (CMT1), Hereditary Neuropathy with liability to Pressure Palsies (HNPP) CMT1/HNPP region, 17p12
P036-Subtelomeres Mix 1CE Subtelomeric testing All subtelomeres
P049-SLC6A8 - ABCD1 Creatine transporter, x-linked SLC6A8, Xq28
P054-FOXL2-TWIST1 Ophthalmogenetic anomalies FOXL2 , TWIST1, FOXC1, FOXC2, ATR, PITX2, GPR143
P061-Lissencephalyimproved Lissencephaly LIS1, DCX, POMT1, POMGnT1, FLNA
P064-MR-1 Mental Retardation; 1p-deletion, Williams, Smith-Magenis, Miller-Dieker, DiGeorge, Prader-Willi, Alagille, Saethre-Chotzen, Sotos Various
P070-Subtelomeres Mix 2BCE Subtelomeric testing All subtelomeres
P075-TCF4-FOXG1 Pitt-Hopkins syndrome, Congential variant of Rett syndrome TCF4, FOXG1
P080-Craniofacial Craniofacial disorders FGFRs, TWIST, MSX2, ALX4, RUNX2
P096-MR-2 Mental retardation, Wolf-Hirschhorn, Cri du Chat, Langer-Giedon, WAGR, Rubinstein-Taybi, Down, Kabuki Various
P106-MRX Mental retardation, x-linked (XLMR) Chromosome X
P122-NF1-area Neurofibromatosis NF1 17q11.2
P137-SCN1A Epilepsy SCN1A 2q24.3
P138-SLC2A1-STXBP1 Glut1 deficiency syndrome SLC2A1, STXBP1
P141-NIPBL-1 Cornelia de Lange syndrome (CDLS) NIPBL 5p13.2
P142-NIPBL-2 Cornelia de Lange syndrome (CDLS) NIPBL 5q13.1
P147-1p36 1p36 deletion syndrome 1p36
P160-STS Steroid Sulfatase gene (STS) STS Xp22
P179-Limb-1 Limb malformations GLI3 7p14.1, HOXD13 2q31.1, ROR2 9q22.31
P184-JAG1 Alagille Syndrome (AGS) JAG1 20p12.2
P185-Intersex Sex determination SOX9 17q24.3; NR5A1 9q33; WNT4 1p36.12; CXorf21 & NROB1 Xp21.2
P187-HPE Holoprosencephaly (HPE) PTCH, SHH, ZIC2, SIX3, TGIF TMEM1, FBXW11
P188-22q13 Phelan-Mcdermid syndrome, Telomeric monosomy 22q13.3 22q13.3, SHANK3, ACR, RABL2B
P189-CDKL5 Rett syndrome, atypical CDKL5 Xp22, NTNG1 1p13.3, ARX Xp21.3
P201-CHARGE CHARGE syndrome CHD7 8q12.2
P208-Human Telomere-6 Subtelomeric testing 2p, 3p, 6p, 8p
P219-PAX6 Ocular malformations, hereditary PAX6 11p13, SOX2 3q26, WT1, 11p13
P228-TRPS1-EXT1 Trichorhinophalangeal syndrome type I (TRPS1), Langer-Giedion syndrome (LGS) TRPS1, EXT1, 8q24
P230-Human Telomere-7 Subtelomeric testing 9p, 10p, 11p, 12p
P234-GATA3 - GATA4 Cardiac septal defects GATA4 8p23, GATA3 10p15
P245-Microdeletion-1 Microdeletion syndromes Various
P249-Human Telomere-8 Subtelomeric testing 17p, 18p, 19p, 20p
P250-DiGeorgeCE DiGeorge syndrome 22q11
P267-Dandy-Walker Dandy-Walker Malformation (DWM) ZIC1, ZIC4 3p2, VLDLR 9p24
P275-MAPT-GRN Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration, progressive supranuclear palsy MAPT 17q21
P277-Human Telomere-10 Subtelomeric testing 5q, 6q, 7q, 8q
P286-Human Telomere-11 Subtelomeric testing 9q, 10q, 11q, 12q
P289-LMX1B Nail patella syndrome (NPS) LMX1B 9q33
P291-Human Telomere-12 Subtelomeric testing 13q, 14q, 15q, 16q
P297-Microdeletion-2 Microdeletion syndromes Various
P304-IRF6-GRHL3 Van der Woude syndrome (VWS) IRF6, 1q32.2; GRHL3 1p36.11
P313-CREBBP Rubinstein–Taybi syndrome (RSTS) CREBBP 16p13.3
P320-Human Telomere-13 Subtelomeric testing 17q, 18q, 19q, 20q.
P333-EP300 Rubinstein–Taybi syndrome (RSTS) EP300; 22q13.2
P336-UBE3A Angelman UBE3A, MTHFR, GABRB3
P339-SHANK3 Autism Spectrum Disorder SHANK3 22q13.33
P343-Autism-1 Autism 15q11-13: UBE3A, GABRB3; 16p11; SHANK3 22q13
P356-Chromosome 22q Subtelomeric testing 22q11, 22q13
P358-Human Telomere-15 Subtelomeric testing 4p, 5p telomeres and 13q,14q centromere regions
P360-Y-Chromosomebasic research Y-Chromosome Microdeletions Chromosome Y
P365-Human Telomere-14 Subtelomeric testing 7p, 15q-cen, 16p, 21q-cen, 21q
P369-Smith-Magenis Smith-Magenis syndrome 17p11.2
P371-Microdeletion-5 Microdeletion follow-up 2p16, Langer Giedion, 9q22, WAGR, 15q24, 17q21
P372-Microdeletion-6 Microdeletion follow-up Sotos, DiGeorge, Rubinstein-Taybi, NF1
P373-Microdeletion-7 Microdeletion follow-up 1p36, 3q29, Wolf-Hirschhorn, Cri du Chat, Phelan-McDermid
P374-Microdeletion-8 Microdeletion follow-up: 7q11, PWS/AS, Miller-Dieker, Smith-Magenis, RETT 7q11, PWS/AS, Miller-Dieker, Smith-Magenis, RETT
P379-NRXN1 Pitt-Hopkins-like syndrome 2 NRXN1
P387-NPHP1 Nephronophthisis 1 NPHP1 2q13
P395-MEF2C-FOXG1 mental retardation MEF2C 5q14.3, FOXG1 14q12
P405-CMT1CE Charcot Marie Tooth Disease CMT/HNPP region at 17p12
P426-Cystinuria Cystinuria SLC3A1, 2p12 and SLC7A9
P431-FOXF1 Alveolar capillary dysplasia 2p24.3 (MYCN) and 16q24.1 (FOXF1; FOXC2; FOXL1)
P443-KANSL1 KANSL1 copy number 17q21.31
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