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SALSA MLPA Reagent Kits for Neuromuscular

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SALSA MLPA Reagent Kits for Neuromuscular
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.
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Features & Benefits

  • Neuromuscular Disorder Detection
  • Simultaneous Detection of copy number, methylation and known point mutation
  • Low Input - Requires only 50 ng of DNA
  • Reproducible - High concordance with other techniques
  • Time Efficient - Results available within 24 hrs.
  • High Throughput - Can detect up to 60 sequences in 96  DNA samples, in one reactions
  • Cost Effective

Product Details

MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.


Components provided per SALSA MLPA Reagent Kit  



  • SALSA MLPA Buffer (yellow cap)

  • SALSA Ligase-65 (green cap)

  • Ligase Buffer A (transparent cap)

  • Ligase Buffer B (white cap)

  • SALSA PCR Primer Mix (brown cap)

  • SALSA Polymerase (orange cap) 


MLPA has the following solutions for Neuromuscular:



























































































































































PRODUCT NAME APPLICATION REGION
P021-SMA Spinal Muscular Atrophy (SMA) SMN1, SMN2, 5q13
P033-CMT1CE Charcot-Marie Tooth disease (CMT1), Hereditary Neuropathy with liability to Pressure Palsies (HNPP) CMT1/HNPP region, 17p12
P034-DMD-1CE Duchenne Muscular Dystrophy (DMD) DMD, Xp21.2
P035-DMD-2CE Duchenne Muscular Dystrophy (DMD) DMD, Xp21.2
P048-LMNA/MYOT/ZMPSTE24 Laminopathies, Limb-girdle muscular dystrophy, Myofibrillar myopathies LMNA 1q22; ZMPSTE24 1p34; MYOT 5q31; CAV3 3p25
P058-IGHMBP2 Distal spinal muscular atrophy 1 (DSMA1), SMARD1, dHMN6 IGHMBP2 11q13
P060-SMACE Spinal Muscular Atrophy (SMA) SMN1, SMN2, 5q13
P061-Lissencephalyimproved Lissencephaly LIS1, DCX, POMT1, POMGnT1, FLNA
P074-AR Androgen insensitivity syndrome (AIS) AR Xq12
P116-SGC Limb-girdle muscular dystrophy (LGMD) SGCA, SGCB, SGCD, SGCG, FKRP
P129-GJB1 Charcot Marie Tooth disease, x-linked GJB1 Xq13.1
P143-MFN2-MPZ Charcot-Marie-Tooth disease (CMT2A/1B) MFN2 1p36.2, MPZ 1q22
P176-CAPN3 Limb girdle muscular dystrophy 2A (LGMD2A) CAPN3 15q15.1
P268-DYSF Limb girdle muscular dystrophies (LGMD) DYSF 2p13
P279-CACNA1A Episodic ataxia 2, Familial hemiplegic migraine CACNA1A
P307-SEPT9 Hereditary neuralgic amyotrophy (HNA) SEPT9 17q25.3
P309-MTM1 Myotubular myopathy, x-linked (XLMTM) MTM1 Xq28, MTMR1 Xq28
P326-LARGE Walker-Warburg Syndrome LARGE, FKTN, POMT2
P348-ATP1A2-CACNA1Aimproved Migraine 1q23, 19p13
P350-CLCN1-KCNJ2 Myotonia congenita, Thomsen’s disease, Becker’s disease, Andersen-Tawil syndrome CLCN1, KCNJ2
P353-CMT4 autosomal recessive demyelinating form SH3TC2; NEFL; GDAP1; EGR2; SBF2; MTMR2; PRX
P391-LAMA2 mix 1 CMD, Merosin-deficient 6q22.33
P392-LAMA2 mix 2 CMD, Merosin-deficient 6q22.33
P397-SCN4A-CACNA1S nondystrophic myotonias and primary periodic paralyses CACNA1S, SCN4A
P405-CMT1CE Charcot Marie Tooth Disease CMT/HNPP region at 17p12
P406-CMT2 CMT2B/2D/2F various
P436-ANO5 Limb-girdle muscular dystrophy ANO5 gene
P453-GAA Pompe Disease 17q25.3
P460-SMAbasic research Spinal muscular Athrophy 5q13.2
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