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SALSA MLPA Reagent Kits for Skin

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SALSA MLPA Reagent Kits for Skin
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.
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Features & Benefits

  • Detection of Skin Disorders
  • Simultaneous Detection of copy number, methylation and known point mutation
  • Low Input - Requires only 50 ng of DNA
  • Reproducible - High concordance with other techniques
  • Time Efficient - Results available within 24 hrs.
  • High Throughput - Can detect up to 60 sequences in 96  DNA samples, in one reactions
  • Cost Effective

Product Details

MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.


Components provided per SALSA MLPA Reagent Kit  



  • SALSA MLPA Buffer (yellow cap)

  • SALSA Ligase-65 (green cap)

  • Ligase Buffer A (transparent cap)

  • Ligase Buffer B (white cap)

  • SALSA PCR Primer Mix (brown cap)

  • SALSA Polymerase (orange cap) 


MLPA has the following solutions for Skin:





























































































































PRODUCT NAME APPLICATION REGION
ME024-9p21 Tumours, Cutaneous melanoma 9p21, CDKN2A, CDKNA2B
P046-TSC2 Tuberous Sclerosis TSC2 16p13.3
P067-PTCH Gorlin syndrome PTCH 9q22.3
P073-IKBKG Incontinentia Pigmenti Xq28; IKBKG, NEMO, IKBKGP
P081-NF1 mix 1 Neurofibromatosis NF1 17q11.2
P082-NF1 mix 2 Neurofibromatosis NF1 17q11.2
P092-ABCC6 Pseudoxanthoma elasticum ABCC6 16p13.11
P122-NF1-area Neurofibromatosis NF1 17q11.2
P124-TSC1 Tuberous Sclerosis TSC1 9q34
P160-STS Steroid Sulfatase gene (STS) STS Xp22
P186-PAX3-MITF-SOX10 Waardenburg syndrome (WS) type II, WS1, WS3 PAX3 2q35, MITF 3p14, SOX10 22q13.1
P256-FLCN Birt-Hogg-Dube syndrome FLCN 17p11, Smith-Magenis syndrome region
P257-TERT-DKC1 Dyskeratosis congenita (DC) DKC1 Xq28
P289-LMX1B Nail patella syndrome (NPS) LMX1B 9q33
P295-SPRED1 SPRED1 SPRED1 15q14
P325-OCA2 oculocutaneous albinism OCA2 15q12; TYR 11q14.3
P337-TSC2 Tuberous sclerosis TSC2 gene, 16p13.3
P354-KIT SNAI2 Piebaldism/KIT KIT 4q12, SNAI2 8q11
P411-Porphyria mix 1 Porphyrias ALAD, HMBS, PPOX
P412-Porphyria mix 2 Porphyrias FECH, UROS, UROD, CPOX
P415-COL7A1-KRT5 Epidermolysis Bullosa Hereditaria 3p21.31 COL7A1, 12q13.13 KRT5
P416-KRT14-LAMA3-LAMB3-LAMC2 Epidermolysis Bullosa Hereditaria 17q21.2 KRT14; 18q11.2 LAMA3; 1q32.2 LAMB3; 1q25.3 LAMC2
P419-CDKN2A/2B-CDK4 Familial melanoma CDKN2A, CDKN2B, CDK4, MITF E318K
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