SALSA MLPA Reagent Kits for Skin

MRC HOLLAND SALSA MLPA Reagent Kits for Skin in India

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SALSA MLPA Reagent Kits for Skin
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.
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Features & Benefits

  • Detection of Skin Disorders
  • Simultaneous Detection of copy number, methylation and known point mutation
  • Low Input - Requires only 50 ng of DNA
  • Reproducible - High concordance with other techniques
  • Time Efficient - Results available within 24 hrs.
  • High Throughput - Can detect up to 60 sequences in 96  DNA samples, in one reactions
  • Cost Effective

Product Details

MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.


Components provided per SALSA MLPA Reagent Kit  



  • SALSA MLPA Buffer (yellow cap)

  • SALSA Ligase-65 (green cap)

  • Ligase Buffer A (transparent cap)

  • Ligase Buffer B (white cap)

  • SALSA PCR Primer Mix (brown cap)

  • SALSA Polymerase (orange cap) 


MLPA has the following solutions for Skin:





























































































































PRODUCT NAMEAPPLICATIONREGION
ME024-9p21Tumours, Cutaneous melanoma9p21, CDKN2A, CDKNA2B
P046-TSC2Tuberous SclerosisTSC2 16p13.3
P067-PTCHGorlin syndromePTCH 9q22.3
P073-IKBKGIncontinentia PigmentiXq28; IKBKG, NEMO, IKBKGP
P081-NF1 mix 1NeurofibromatosisNF1 17q11.2
P082-NF1 mix 2NeurofibromatosisNF1 17q11.2
P092-ABCC6Pseudoxanthoma elasticumABCC6 16p13.11
P122-NF1-areaNeurofibromatosisNF1 17q11.2
P124-TSC1Tuberous SclerosisTSC1 9q34
P160-STSSteroid Sulfatase gene (STS)STS Xp22
P186-PAX3-MITF-SOX10Waardenburg syndrome (WS) type II, WS1, WS3PAX3 2q35, MITF 3p14, SOX10 22q13.1
P256-FLCNBirt-Hogg-Dube syndromeFLCN 17p11, Smith-Magenis syndrome region
P257-TERT-DKC1Dyskeratosis congenita (DC)DKC1 Xq28
P289-LMX1BNail patella syndrome (NPS)LMX1B 9q33
P295-SPRED1SPRED1SPRED1 15q14
P325-OCA2oculocutaneous albinismOCA2 15q12; TYR 11q14.3
P337-TSC2Tuberous sclerosisTSC2 gene, 16p13.3
P354-KIT SNAI2Piebaldism/KITKIT 4q12, SNAI2 8q11
P411-Porphyria mix 1PorphyriasALAD, HMBS, PPOX
P412-Porphyria mix 2PorphyriasFECH, UROS, UROD, CPOX
P415-COL7A1-KRT5Epidermolysis Bullosa Hereditaria3p21.31 COL7A1, 12q13.13 KRT5
P416-KRT14-LAMA3-LAMB3-LAMC2Epidermolysis Bullosa Hereditaria17q21.2 KRT14; 18q11.2 LAMA3; 1q32.2 LAMB3; 1q25.3 LAMC2
P419-CDKN2A/2B-CDK4Familial melanomaCDKN2A, CDKN2B, CDK4, MITF E318K
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