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SALSA MLPA Reagent Kits for Visual Impairment

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SALSA MLPA Reagent Kits for Visual Impairment
MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.
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Features & Benefits

  • Detection of Visual Impairment Disorders
  • Simultaneous Detection of copy number, methylation and known point mutation
  • Low Input - Requires only 50 ng of DNA
  • Reproducible - High concordance with other techniques
  • Time Efficient - Results available within 24 hrs.
  • High Throughput - Can detect up to 60 sequences in 96  DNA samples, in one reactions
  • Cost Effective

Product Details

MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR method that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be handled simultaneously with results being available within 24 hours.


Components provided per SALSA MLPA Reagent Kit  



  • SALSA MLPA Buffer (yellow cap)

  • SALSA Ligase-65 (green cap)

  • Ligase Buffer A (transparent cap)

  • Ligase Buffer B (white cap)

  • SALSA PCR Primer Mix (brown cap)

  • SALSA Polymerase (orange cap) 


MLPA has the following solutions for Visual Impairment:





































































































































































PRODUCT NAME APPLICATION REGION
P027-Uveal melanoma Uveal melanoma 1p, chr.3, 6p, 8q
P047-RB1 Retinoblastoma (RB) RB1 13q14
P054-FOXL2-TWIST1 Ophthalmogenetic anomalies FOXL2 , TWIST1, FOXC1, FOXC2, ATR, PITX2, GPR143
P065-Marfan-1 Marfan syndrome FBN1 15q21.1, TGFBR2 3p22
P066-Marfan-2 Marfan syndrome FBN1 15q21.1
P092-ABCC6 Pseudoxanthoma elasticum ABCC6 16p13.11
P151-ABCA4 mix-1 Stargardt, Macular dystrophy, Retinitis pigmentosa, age-related macular degeneration, cone rod dystrophies ABCA4 (ABCR) 1p22.1
P152-ABCA4 mix-2 Stargardt, Macular dystrophy, Retinitis pigmentosa, age-related macular degeneration, cone rod dystrophies ABCA4 (ABCR) 1p22.1
P219-PAX6 Ocular malformations, hereditary PAX6 11p13, SOX2 3q26, WT1, 11p13
P221-LCA mix-1 Leber congenital amaurosis (LCA) AIPL1 17p13, CRB1 1q31, CRX 19q13, RPE65 1p31
P222-LCA mix-2 Leber congenital amaurosis (LCA) GUCY2D 17p13.1, RDH12 14q24, RPGRIP1 14q11, CEP290 12q21
P229-OPA1 Macular dystrophy OPA1 3q28, VMD2 11q13, RDS 6p21.2
P235-Retinitis Retinitis Pigmentosa RHO 3q21.3, RP1 8q11.2, IMPDH1 7q32, PRPF31 19q13.4
P236-ARMD mix-1basic research Age-related macular degeneration (ARMD) CFH, CFHR3, CFHR1, CFHR2, 1q23
P269-FRMD7 Congenital nystagmus Xq26 (NYS1 locus), FRMD7
P285-LRP5 Osteoporosis-pseudoglioma syndrome (OPPS) LRP5 11q13.4, DKK1 10q11.2
P292-PCDH15 Usher syndrome PCDH15 10q21.1
P310-TCOF1 Treacher Collins-Franceschetti 1 TCOF1
P313-CREBBP Rubinstein–Taybi syndrome (RSTS) CREBBP 16p13.3
P325-OCA2 oculocutaneous albinism OCA2 15q12; TYR 11q14.3
P326-LARGE Walker-Warburg Syndrome LARGE, FKTN, POMT2
P328-EYS Retinitis Pigmentosa EYS 6q12
P333-EP300 Rubinstein–Taybi syndrome (RSTS) EP300; 22q13.2
P361-USH2A mix 1 Usher syndrome USH2A 1q41
P362-USH2A mix 2 Usher syndrome USH2A 1q41
P366-CHM-RP2-RPGR Retinitis pigmentosa (RP) CHM-RP2-RPGR
P367-BEST1-PRPH2 Macular Dystrophy, Vitelliform BEST1 (=VDM2), PRPH2 (=RDS)
P381-COL11A1 mix 1 Marshall, type II Stickler syndromes COL11A1
P382-COL11A1 mix 2 Marshall, type II Stickler syndromes COL11A1
P470-NCL Neuronal Ceroid Lipofuscinoses/Batten Disease 01p34.2, 08p23.3, 11p15.4, 15q23, 16p11.2
P473-CTNSnew (Nephropathic) Cystinosis 17p13.2
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