Cytotoxic drugs are therapeutic agents intended for, but not limited to, the treatment of cancer. These drugs are known to be highly toxic to cells, mainly through their action on cell reproduction. Many have proved to be carcinogens, mutagens or teratogens. Cytotoxic drugs are increasingly being used in a variety of healthcare settings, laboratories and veterinary clinics for the treatment of cancer and other medical conditions such as rheumatoid arthritis, multiple sclerosis and auto-immune disorders. Health effects attributed to exposure to occupational cytotoxic drugs can be very serious. Research shows that where a high standard of risk control is in place, threats to healthcare are reduced.
No exposure limits are set for cytotoxic drugs. Medical opinion is such that even low-level exposure to cytotoxic drugs should be avoided as much as possible. Research has shown that the implementation of suitable safety precautions reduces the incidence of adverse health effects. EuroClone cytotoxic drugs handling Cabinet S@femate® Cyto, has been designed according to DIN12980 and EN12469:2000 standards and provides the laboratory technician with the maximum level of safety against inhalation of aerosols generated during the reconstitution protocols.
These last generation Cytotoxic drug handling Cabinets have been designed according with the most stringent safety standards for this category of Safety Cabinets (DIN12980, EN12469). The internal design, the air flow aerodynamics and monitoring, the built-in safety devices and the very accurate manufacturing, guarantees the highest performances at the most stringent safety levels, as specified by DIN 12980 and EN12469. Intrinsic safety, combined with impressively competitive prices, gives the end user a state of the art cabinet accessible to every budget, that only experienced European design and accurate quality manufacturing, can provide.
Other than the two classic H14 filters needed for the filtration of exhausted air and downflow recirculating unidirectional airflow, a tertiary filtration stage (with bag-in bag-out filter changing protocol according to KTA 3601 Lüftungstechnische Anlagen in Kernkraftwerken) is located underneath the work surface in order to provide, by filtering 100% of the recirculated airflow, the required safety for the maintenance personnel when removing this stage of filtration for substitution
Four levels of safety are therefore provided:
- Safety for the operator, (extremely high Aperture protection factor) identical to the one provided by a Biological Safety Cabinet
- Safety for the environment (double H14 filtration stage in the exhaust)
- Safety for the product and between products (class 100 in the work area)
- Safety for the engineers when changing the tertiary filter stage (bag-in bag-out procedure)