InteGen LLC provides two types of ICP-based DNA FISH probes: one for proﬁling chromosomes in standard resolution and one for proﬁling chromosomes in high resolution. InteGen LLC’s novel products may be protected by one or more patents in numerous jurisdictions throughout the world.
All probes are manufactured in the United States at InteGen LLC’s manufacturing headquarters in Orlando, Florida. The facility is compliant with the U.S Food and Drug Administration’s quality system and cGMP standards.
NO MORE NO GROWTH with ICP
With ICP, Cytogeneticists Never Again Sign a Failed Cytogenetics Report
The ICP concept is very simple. Individual chromosomes are studied in their uncondensed state in an interphase nucleus using a panel of FISH probes that target DNA sequences in an equidistant fashion along the entire length of the chromosome. Using only three fluorophores for each chromosome arm, one can “walk” along the whole chromosome in a sequential manner using standard fluorescence microscopy. The resolution obtained with ICP technology is approximately 600 bands, sufficient to detect numerical changes and all clinically relevant structural abnormalities from clinical samples. Some targets are read once while others are read twice with two different fluorophores. The resulting “banding pattern” is distinct with each target molecularly different from its neighboring target or any other target on that chromosome.