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TOP2A IQFISH pharmDx Kit

TOP2A IQFISH pharmDx Kit
TOP2A IQFISH pharmDx is designed to detect amplifications and deletions (copy number changes) of the TOP2A gene using fluorescence in situ hybridization (FISH) technique on formalin-fixed, paraffin-embedded human breast cancer tissue specimens.
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Our pharmDx Solution is a portfolio of all-in-one pharmDx kits that lead to optimal diagnostic results within companion diagnostics. Correct results the first time help select the right therapy for each patient - every time. pharmDx is all about personalized medicine pharmDx kits make a difference to the assessment of patient treatment. The validated kits have the right specificity and sensitivity. Correct results the first time lead to fewer reruns and will help select the right therapy for each patient - every time. We help improve patient care by delivering fast results with great confidence and reducing time from biopsy to diagnosis.

Type II topoisomerases are essential enzymes that play important roles in fundamental nuclear processes such as DNA replication and recombination. The TOP2A gene is approximately 30 kb in size and encodes a 170 kDa protein. The TOP2A protein has been recognized as a proliferation marker and is expressed in proliferating cells and in numerous human malignant tumors, including colon, gastric and breast cancer, lymphomas and others. Type II topoisomerases are the targets for anticancer drugs, such as the topoisomerase II inhibitor therapies like the anthracyclines Doxorubicin and Epirubicin.

TOP2A IQFISH pharmDx is designed to detect amplifications and deletions (copy number changes) of the TOP2A gene using fluorescence in situ hybridization (FISH) technique on formalin-fixed, paraffin-embedded human breast cancer tissue specimens. Deletions and amplifications of the TOP2A gene serve as markers for poor prognosis in high-risk breast cancer patients. TOP2A gene amplification detected by the TOP2A IQFISH pharmDx is further indicated as an aid to predict recurrence-free and overall survival in high-risk breast cancer patients treated with adjuvant epirubicin-based chemotherapy.
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