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Chromosome Resolution Additive

Chromosome Resolution Additive
CRA (Chromosome Resolution Additive) is a ProCell Cytogenetics Reagent that prevents chromosome contraction and encourages chromosome elongation by loosening the chemical bonding within the supercoiled structure of the chromosome.
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Product Details

ProCell Cytogenetics Reagents product range was developed in collaboration with scientists working in a clinical oncology cytogenetics unit. The ProCell range is designed to improve culture failure rates, mitotic index, metaphase spreading, banding resolution and overall quality of bone marrow, lymphoma, solid tumour, blood, CVS and Amniocentesis samples for cytogenetic analysis.

Chromosome Resolution Additive (CRA) is a newly discovered commercial formulation that consistently prevents chromosome contraction and encourages chromosome elongation by loosening the chemical bonding within the supercoiled structure of the chromosome. The result is prophase quality chromosomes. It was developed especially for tissues resistant to existing prophase techniques, such as bone marrows and solid tumour samples. CRA contains no ethidium bromide or thymidine.

CRA is a simple-to-use product that increases chromosome resolution and is safer than ethidium bromide. A working solution of CRA is simply
added to the culture up to 90 minutes prior to metaphase arrest.
This product has been shown to increase QA band level on different cytogenetics sample types. CRA is a colchicine antagonist, this means that it reduces the chromosome shortening effect of colchicine. CRA can also be used alongside ethidium bromide for extra chromosome length.
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