Clonality
Lymphoid cells are different from the other somatic cells in the body as during development, the antigen receptor genes in lymphoid cells undergo somatic gene arrangement. Leukemia & lymphomas originate from the malignant transformation of individual lymphoid cells. Therefore, all leukemias and lymphomas generally have one or more cell-specific or 'clonal' antigen receptor gene rearrangements. Clonality does not always imply malginancy; all results must be interpreted in the context of all other available indicative characteristics. IVS assays detect clonal rearrangements & can therefore prove to be useful in the characterization and treatment of B- and T-cell malignancies.
-
ABI Fluorescence Detection is done using ABI 310, 3100 & 3130 instruments.
ADD TO SHORTLIST -
Gel Detection is done using Agarose TBE Gels,Polyacrylamide TBE Gels,Heteroduplex Analysis
ADD TO SHORTLIST -
Controls play a crucial role in invalidation. Invivoscribe provides controls manufactured in cGMP conditions.
ADD TO SHORTLIST -
The MiSeq helps in analysing clonal amplification, genomic DNA sequencing, and data analysis in a single run.
ADD TO SHORTLIST -
Thermofisher's Ion PGM™ or Ion S5™platforms help in targeted gene sequencing in oncology and genetic disorders.
ADD TO SHORTLIST -
ABI Fluorescence Detection is done using ABI 310, 3100 & 3130 instruments.
ADD TO SHORTLIST -
Gel Detection is done using Agarose TBE Gels,Polyacrylamide TBE Gels,Heteroduplex Analysis
ADD TO SHORTLIST
