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SALSA® digital Multiplex Ligation-dependent Probe Amplification (digitalMLPA) is a multiplex PCR followed by Illumina sequencing-based amplicon quantification, for the detection of copy number variations (CNV) and specific point mutations.
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Methylation-Specific (MS)-MLPA® is a variant of the MLPA technique, the gold standard in copy number determination. With MS-MLPA, it is possible to semi-quantitatively profile methylation for multiple targets simultaneously.
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MLPA Assays are useful in finding out those who have Lung Disorders
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MLPA can be used for the detection of deletions or duplications of certain genes involved in cardiovascular diseases.
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MLPA Assays are useful in finding out those who have hereditary blood disorders.
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MLPA Assays are useful in finding out those who have Skeletal & Connective Tissue Disorders
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MLPA Assays are useful in tumor profiling for blood cancer, solid tumors as well as general tumor profiling
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SALSA® MLPA® Probemixes for Cancer Predisposition are used for determining DNA copy number variations in individuals who have a genetic predisposition to various cancers, including breast, ovarian, colorectal, endometrial, gastric, and small bowel cancer, among others. MLPA Assay is a simple, robust and multiplex PCR-based assay.
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SALSA® MLPA® Probemixes for Congenital Disorders & Carrier Testing are used for determining DNA copy number variations in inherited disorders such as Alpha-Thalassemia (P140 HBA) , Congenital Adrenal Hypoplasia (P050 CAH), Cystic Fibrosis (P091 CFTR), Duchenne Muscular Dystrophy (P034 DMD-1; P035 DMD-2) and Spinal Muscular Atrophy (P021 SMA; P060 SMA Carrier; P460 SMA (Silent) Carrier).
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SALSA® Methylation - Specific (MS) - MLPA® Probemixes for Imprinting Disorders are used for determining DNA copy number variations and methylation status associated with conditions like Prader-Willi Syndrome, Angelman Syndrome, Beckwith-Wiedemann and Russell-Silver Syndrome.
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The SALSA digitalMLPAProbemix D006-A1 Multiple Myeloma is a research use only (RUO) assay for the detection of deletions, gains or amplifications of genes and chromosomal regions mentioned in Table 2 that are recurrently altered in multiple myeloma, such as 1p, 1q, 13q and 17p, as well as for the detection of BRAF p.V600E point mutation.
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The SALSA digitalMLPA Probemix D007-A1 Acute lymphocytic leukemia is a research-use-only (RUO) assay for the detection of deletions, gains or amplifications in 52 specific target genes and three chromosomal regions (5q, iAMP21 and PAR1), which are related to acute lymphoblastic leukemia (ALL).
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SALSA® Melt Assays are designed for the fast and reliable screening of a small number of targets in a large number of samples.
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MRC-Holland Products in India
MRC Holland is a company based out of The Netherlands which has a proprietary technology - MLPA® (Multiplex Ligation-dependant Probe Amplification (MLPA®), a multiplex PCR method which enables detection of variation in copy number (CNV) of up to 60 DNA sequences in one reaction and can handle up to 96 DNA samples at a stretch with results being available within 24 hours.
Introduced in 2002, MLPA® is a gold standard in CNV detection and has proven to be a robust and easy-to-use techniques, and since it is highly sensitive to even a single nucleotide difference, it has applications in detection of point mutations.
MLPA®, when used in combination with a methylation-sensitive restriction enzyme, can be applied to detect DNA methylation patterns (MS_MLPA®). The first Melt Assay for spinal muscular atrophy (SMA) newborn screening was launched in 2018 and the first digitalMLPA® technique based assay was launched in 2020. digitalMLPA® combines the trusted quality of MLPA® with the power of next-generation sequencing to examine many more target sequences in a single reaction.
In diagnostics and research of both human genetic disorders and tumors, MLPA® is used in laboratories worldwide.
