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Epidermal growth factor receptor (EGFR) is a membrane protein that plays a central role in sending signals that promote cell growth and proliferation. Its tyrosine kinase (TK) domain triggers several downstream effectors that lead to the activation of the Ras-Raf-MAPK track. Overexpression and oncogenic mutations that constitutively activate the TK domain of EGFR have been found in various solid tumours. Additionally, excessive activation of EGFR is associated with advanced stages of cancer and a poor prognosis.
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The detection of genetic aberrations in solid tumors with DNA Fluorescence in situ Hybridization (FISH) probe technology is a powerful means to diagnose and more efficiently treat a wide range of cancers. Vysis offers a comprehensive line of direct labeled DNA probes for solid tumor assessment.
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