DSS: Redefining Biotechnology & Life Science in India
Home > Products & Services > Kits Reagents & Consumables > Multiplex Ligation-Dependent Probe Amplification (MLPA)
Multiplex Ligation-Dependent Probe Amplification (MLPA)
MLPA is a semi-quantitative technique used to detect copy number variation associated with a disease. It was developed as a proprietary technology by MRC Holland for the detection of copy number variations which is considered the gold standard in this field and now being used all over the world to study tumours and hereditary disorders. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR based technology that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be processed contemporaneously with results being available within 24 hours. Over 350 assays targeting various genetic diseases are available.
DSS Imagetech Pvt Ltd is the sole authorised distributor for MRC Holland in India. We supply assays available with the MRC Holland portfolio. We also provide all possible technical support for our customers whenever needed. Customers are trained on assays and the software from our part.
MLPA Assays for Neuromuscular Disorders
MLPA Assays are useful in finding out those who have Neuromuscular Disorders
MLPA Assays for Skeletal & Connective Tissue
MLPA Assays are useful in finding out those who have Skeletal & Connective Tissue Disorders
MLPA Assays for Lung Disorders
MLPA Assays are useful in finding out those who have Lung Disorders
MLPA Assays for Intellectual Disability
MLPA Assays are useful in finding out those who have Intellectual Disability
MLPA Assays for Hereditary Blood Disorders
MLPA Assays are useful in finding out those who have hereditary blood disorders.
MLPA Assays for Endocrinological Disorders
MLPA Assays are useful in finding out those who have endocrinological diseases.
MLPA Assays for Cardiovascular Disorders
MLPA can be used for the detection of deletions or duplications of certain genes involved in cardiovascular diseases.
MLPA Assays for Tumour Profiling
MLPA Assays are useful in tumor profiling for blood cancer, solid tumors as well as general tumor profiling
Methylation-Specific MLPA Assays
Methylation-Specific (MS)-MLPA® is a variant of the MLPA technique, the gold standard in copy number determination. With MS-MLPA, it is possible to semi-quantitatively profile methylation for multiple targets simultaneously.
SALSA® Melt Assays
SALSA® Melt Assays are designed for the fast and reliable screening of a small number of targets in a large number of samples.
D001 Hereditary Cancer Panel
SALSA® digital Multiplex Ligation-dependent Probe Amplification (digitalMLPA) is a multiplex PCR followed by Illumina sequencing-based amplicon quantification, for the detection of copy number variations (CNV) and specific point mutations.
SALSA® digitalMLPA Probemix D006 Multiple Myeloma
The SALSA digitalMLPAProbemix D006-A1 Multiple Myeloma is a research use only (RUO) assay for the detection of deletions, gains or amplifications of genes and chromosomal regions mentioned in Table 2 that are recurrently altered in multiple myeloma, such as 1p, 1q, 13q and 17p, as well as for the detection of BRAF p.V600E point mutation.
SALSA® digitalMLPA Probemix D007 Acute Lymphoblastic Leukemia
The SALSA digitalMLPA Probemix D007-A1 Acute lymphocytic leukemia is a research-use-only (RUO) assay for the detection of deletions, gains or amplifications in 52 specific target genes and three chromosomal regions (5q, iAMP21 and PAR1), which are related to acute lymphoblastic leukemia (ALL).
Testimonials & Reviews
Dr. (Prof.), Nitesh Mohan
Professor & Head, Department of Pathology, RMCH Bareilly
DSS's expertise, dedication, and professionalism were outstanding in making the Karyotyping & FISH workshop a great success. Their knowledge and valuable insights empowered all the participants with practical skills, receiving highly positive feedback from both students as well as faculty members.
Dr. Chhaya Chande, Professor & HOD, Microbiology
GGMCJJ Hospitals, Mumbai
“Ms. Megha Dhumal (Assistant Manager- Application) has done a satisfactory demonstration of the running of the Abbott Sample preparation machine model m2000sp and the Abbott RT-PCR machine model m2000rt. We appreciate the effort made by the DSS team under these difficult conditions to help our lab to carry out the imperative Covid-19 tests.”
Dr Sunil K Arora, Professor, Deptt of Immunopathology
PGIMER, Chandigarh
“We are using Confocal Microscope and one Fluorescence Microscope. Both are working fine. The after sales services by DSS have been excellent for functioning & upkeep of the microscopes. The applications support by experts from DSS is very useful. Keep it up!”
Dr Pramod Kumar Bajaj
MD, Spermprocessor Pvt Ltd
“Really excited to see the DSS Pathology solutions exhibition booth at APCON 2019 along with Magnus. We think all the upcoming technology had been displayed along with your efforts to make it Indigenous (Made in India) is highly appreciated. Wish you all the best. Keep it up!”
Dr. Sreejesh S, Associate Professor, Dept of Hematology
PGIMER, Chandigarh
“My experience with DSS so far has been very good till now. We are getting good support in both purchase as well as in troubleshooting. Very good experience with Mr Arun, Mr Manoj, Mr Mahesh and all others from the DSS team.”
Dr Sudha S Murthy, Department of Pathology and Laboratory Medicine
BIACH & RI, Hyderabad
“I am happy with DSS and associated with 19 years and use Dako antibody. Happy with Supply but need improvement.”
Dr S Radhika MD, PhD
Professor, Deptt. Of Cytology & Gynaec Pathology, PGIMER, Chandigarh
“PGI Cytology Dept. has had a long association with DSS- Olympus Microscopy Division. They have provided excellent services- after sales service. The product is also of very good quality. We have had no problems with their products and services are of very good quality.”
Dr Nuzhat Husain
RMLIMS, Lucknow
“Have been using Dako Reagents and Dako antibodies for a while. Services and products have been good and timely.”
Dr Minu Singh
Assistant Professor, PGIMER, Chandigarh
“MRC Holland MLPA products provided by DSS are of good quality, have never faced any quality issues with their product or shipping condition. They provide prompt response upon any query.”
Mr. Krishnani Professor, SGPGI, Lucknow
“My experience with DSS so far has been excellent for the last 30 years- sales and service experience. Microscope products are very useful and sturdy with high precision.”
