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Cancer Diagnostics

Cancer is a genetic disease. The uncontrolled proliferation and division of abnormal cells occur when mutated cell DNA inhibits the tumor suppressor gene function. Cancer arises when the cell DNA gets irreversibly damaged. Cancer can affect almost all parts of the human body. The possible factors for developing cancer can be environmental exposure, inheritance, and mutation of DNA that occurs in the cell division process. The cancer cells can also migrate from their original place to other parts through the blood or lymphatic system; this is known as Metastasis. There are many types of Cancer like Carcinoma that occurs in Epithelial cells, Sarcoma that occurs in connective tissue and Leukemia which occurs in Bone marrow. Early detection of cancer is very essential for better treatment and to control the severity.

DSS provides the solution for cancer diagnostics with a range of products like Entrogen Real-time PCR kits, Abbott Vysis FISH probes, MRC Holland MLPA kits, Dako antibodies, Olympus Microscopes, ASI software along with application support for the entire product range.

Cancer Diagnostics
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Tumor Comprehensive Genomic Profiling Panel Assay

The Tumor Comprehensive Genomic Profiling (CGP) Panel Assay is a high-throughput sequencing (NGS)-based solution for the comprehensive analysis of tumor-related genes. Designed for research use only (RUO), it enables precise detection of single nucleotide variations (SNVs), small insertions/deletions (Indels), copy number variations (CNVs), and gene fusions across a 1200-gene panel. Available Test Format: 24 samples/Kit

Hereditary Cancers Panel Assay

The Hereditary Cancers Panel Assay is designed for comprehensive genetic analysis of hereditary tumor-related genes using next-generation sequencing (NGS). This assay enables accurate detection of single nucleotide variations (SNVs) and short insertions/deletions (Indels) across 58 clinically relevant genes associated with hereditary cancer syndromes. Available Test Format: 24 samples/Kit

Human Glioma 26 Gene Mutations Detection Kit (High-Throughput Sequencing)

The Human Glioma 26 Gene Mutations Detection Kit is a high-throughput sequencing (NGS)-based assay for the qualitative detection of key glioma-associated genetic alterations. Designed for research use only, the kit analyzes nucleic acids extracted from FFPE or fresh tissue samples, enabling detection of SNVs, indels, gene fusions, CNVs, and chromosome variations (1p/19q co-deletion, chr7 amplification, […]

Solid Tumors 107 Gene Mutations Detection Kit (High-Throughput Sequencing)

The Solid Tumors 107 Gene Mutations Detection Kit is designed for qualitative detection of 107 tumor-related gene mutations using high-throughput sequencing (NGS). Compatible with both Illumina and MGI sequencing platforms, this kit supports detection of SNVs, indels, gene fusions, CNVs, and MSI from FFPE or fresh tissue samples. Sequencing instruments: Illumina sequencing instruments (Miseq, NextSeq […]

Thyroid Cancer Gene Mutation Detection Kit (High-Throughput Sequencing)

The Thyroid Cancer Gene Mutation Detection Kit is a high-throughput sequencing (NGS) solution designed for the comprehensive detection of key pathogenic mutations associated with thyroid cancer. Using DNA and RNA extracted from fine needle aspiration (FNA) samples or thyroid tissue, the kit covers 16 DNA-level genes and 87 RNA-level genes (209 fusion forms). It detects […]

BRCA1/2 Gene Mutations Detection Kit (High-Throughput Sequencing)

The BRCA1/2 Gene Mutations Detection Kit is designed for the qualitative detection of BRCA1 (NM_007294) and BRCA2 (NM_000059) gene mutations in samples extracted from formalin-fixed paraffin-embedded (FFPE) tissue or peripheral blood of cancer patients. These genes are key biomarkers in hereditary breast and ovarian cancers, consisting of 23 and 27 exons respectively. The assay also […]

Oncology Multi-Gene Mutations Detection Kit (High-Throughput Sequencing)

“Oncology Multi-Gene Mutations Detection Kit (High-Throughput Sequencing) is designed for the detection of 482 somatic mutations across 13 key cancer-related genes in patients with non-small cell lung cancer and colorectal cancer. Using advanced Next Generation Sequencing (NGS) technology and RingCap®-mediated amplification, it enables precise identification of single-base mutations, insertions, deletions, and gene fusions. The kit […]

PD-L1 IHC 22C3 pharmDx

PD-L1 IHC 22C3 pharmDx Advancing Immunotherapy Options Cytotoxic T cells work to detect and eliminate infected cells and tumor cells from the body.

Antibodies & Controls

Primary Antibodies are intended for use on tissue sections whereas control Reagents are well-suited as qualitative negative controls for the primary antibodies.

PD-L1 IHC 28-8 pharmDx

PD-L1 IHC 28-8 pharmDx Advancing Immunotherapy Options Cytotoxic T cells work to detect and eliminate infected cells and tumor cells from the body.

PathVysion

The PathVysion HER-2 DNA Probe Kit II (PathVysion Kit II) is designed to detect amplification of the HER-2/neu gene via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded human breast and gastric cancer tissue specimens.

UroVysion

The UroVysion® Bladder Cancer Kit (UroVysion Kit) is FDA approved and designed to detect aneuploidy for chromosomes 3, 7, 17, and loss of the 9p21 locus via fluorescence in situ hybridization (FISH) in urine specimens from persons with hematuria suspected of having bladder cancer.

D001 Hereditary Cancer Panel

SALSA® digital Multiplex Ligation-dependent Probe Amplification (digitalMLPA) is a multiplex PCR followed by Illumina sequencing-based amplicon quantification, for the detection of copy number variations (CNV) and specific point mutations. 

Entrogen REAL-TIME PCR KITS FOR SAMPLE QUALITY ASSESSMENT

EntroGen’s Sample Quality Assessment kits provide reagents, positive controls, and standards (if applicable) to detect and quantify the amplifiable DNA extracted from patient samples or adaptor-indexed libraries intended for downstream qPCR and NGS assays, respectively.

Entrogen REAL-TIME PCR KITS FOR THYROID CANCER

Thyroid Cancer Mutation Panel provides reagents for detection of point mutations in BRAF and RAS genes, as well as RET/PTC1, 3 and PAX8/PPARγ fusion genes variants.

Entrogen REAL-TIME PCR KITS FOR MELANOMA

Entrogen's kits are polymerase chain reaction (PCR)-based assays that use allele-specific primers in a multiplex reaction to identify the presence of BRAF, NRAS, and c-Kit mutations. The assays work by amplifying mutant-specific sequences in samples that contain a mixture of mutant and wild-type DNA and rely on fluorescent probes for detection. Each reaction contains primer sets and probes for detection of the mutations, as well as an endogenous control gene.

Entrogen REAL-TIME PCR KITS FOR LUNG CANCER

All kits require a real-time PCR instrument capable of detecting FAM and VIC fluorescent probes. Additionally, the Cell-Free EGFR Mutation Detection kit requires the capability to detect ROX and CY5 fluorescent probes.
All reagents required for PCR amplification/detection, as well as validated reaction controls, are included. Columns and reagents for DNA or RNA isolation are not included.

Entrogen REAL-TIME PCR KITS FOR LEUKEMIAS

EntroGen’s One-Step Detection kits provide reagents to detect and quantify the fusion gene transcripts listed below using total RNA isolated from blood or bone marrow.

Entrogen REAL-TIME PCR GENOTYPING KIT

The UGT1A1 Genotyping Kit is a polymerase chain reaction (PCR)-based assay that uses allele-specific probes to identify the most common Irinotecan polymorphic variant.

Entrogen REAL-TIME PCR KITS FOR GASTRO-INTESTINAL STROMAL TUMORS (GIST)

EntroGen’s GIST mutation screening panel is a real-time polymerase chain reaction (PCR)-based assay that uses allele-specific primers to identify the presence of somatic mutations in c-KIT and PDGFRA genes.

Real -Time PCR Kits for Colorectal Cancer

Entrogen's Mutation Analysis Kit requires a real-time thermal cycler capable of detecting FAM and VIC fluorescence signals. This test includes reagents required for the PCR amplification and signal detection, as well as validated reaction controls. Columns and reagents for DNA isolation are not included.

JAK2 V617F Mutation Detection Kit

JAK2 V617F Mutation Detection RT-PCR Kit for sensitive and specific detection of JAK2 (Janus Kinase 2) V617F allele in DNA samples with Beta Actin as an internal control.

Magnetic Bead Nucleic acid Extraction Kit

Discover the benefits of magnetic bead-based kits for nucleic acid purification. Purify high-quality nucleic acids from Biological Samples. Save time and increase consistency using the Magnetic Bead Nucleic Acid Extraction Kit

 

BCR ABL Quantitative RT-PCR Kit – Major

IS quantitative, one-step RT-PCR for quantifying the IS ratios of BCR-ABL Major (M-BCR) p210 transcript in CML patient samples.

BCR ABL Quantitative RT-PCR Kit – Major, Minor, Micro

Evaluates the molecular response up to 5 log reduction which is undetectable BCR-ABL1.

BCR ABL Qualitative RT-PCR Kit – Major, Minor, Micro

Single-Tube, Multiplex Real-Time PCR Assay for sensitive and specific detection of Major (M-BCR) p210, Minor (m-BCR) p190, and Micro (μ-BCR) p230 BCR-ABL transcripts.

BRCA Complete™ Expanded Panel

BRCA Complete™ Expanded Panel is a complete next generation sequencing (NGS) solution for detecting clinically relevant BRCA1 and BRCA2 mutations along with extended coverage of CHEK2, PALB2, RAD51C and TP53.

NGS Targeted Hotspot Panel (THSP)

NGS THSP stands for NGS Targeted Hotspot Panel is supposed to detect the multiple clinically related hotspot mutations in 16 genes across several tumour types. Its comprehensive multi-gene panels identify hundreds of genes and detect thousands of variants, many of which have unknown factors.

Melanoma panel

It is estimated that 10% of melanoma cases are attributed to hereditary predisposition.

Hepatocarcinoma Panel

Hepatoma is called hepatocellular carcinoma (HCC) and hepatocarcinoma, it is the most common kind of primary liver malignancy.

Breast Panel

The Breast Cancer Comprehensive Panel analyzes 20 genes related to an expanded risk of hereditary breast cancer.

Neuropathology panels

Neuropathology panels focus and evaluate all aspects of neurodegeneration.

Testimonials & Reviews

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Dr. (Prof.), Nitesh Mohan
Dr. (Prof.), Nitesh Mohan
Professor & Head, Department of Pathology, RMCH Bareilly

DSS's expertise, dedication, and professionalism were outstanding in making the Karyotyping & FISH workshop a great success. Their knowledge and valuable insights empowered all the participants with practical skills, receiving highly positive feedback from both students as well as faculty members.

Dr. Chhaya Chande, Professor & HOD, Microbiology
Dr. Chhaya Chande, Professor & HOD, Microbiology
GGMCJJ Hospitals, Mumbai

“Ms. Megha Dhumal (Assistant Manager- Application) has done a satisfactory demonstration of the running of the Abbott Sample preparation machine model m2000sp and the Abbott RT-PCR machine model m2000rt. We appreciate the effort made by the DSS team under these difficult conditions to help our lab to carry out the imperative Covid-19 tests.”

Dr Sunil K Arora, Professor, Deptt of Immunopathology
Dr Sunil K Arora, Professor, Deptt of Immunopathology
PGIMER, Chandigarh

“We are using Confocal Microscope and one Fluorescence Microscope. Both are working fine. The after sales services by DSS have been excellent for functioning & upkeep of the microscopes. The applications support by experts from DSS is very useful. Keep it up!”

Dr Pramod Kumar Bajaj
Dr Pramod Kumar Bajaj
MD, Spermprocessor Pvt Ltd

“Really excited to see the DSS Pathology solutions exhibition booth at APCON 2019 along with Magnus. We think all the upcoming technology had been displayed along with your efforts to make it Indigenous (Made in India) is highly appreciated. Wish you all the best. Keep it up!”

Dr. Sreejesh S, Associate Professor, Dept of Hematology
Dr. Sreejesh S, Associate Professor, Dept of Hematology
PGIMER, Chandigarh

“My experience with DSS so far has been very good till now. We are getting good support in both purchase as well as in troubleshooting. Very good experience with Mr Arun, Mr Manoj, Mr Mahesh and all others from the DSS team.”

Dr Sudha S Murthy, Department of Pathology and Laboratory Medicine
Dr Sudha S Murthy, Department of Pathology and Laboratory Medicine
BIACH & RI, Hyderabad

“I am happy with DSS and associated with 19 years and use Dako antibody. Happy with Supply but need improvement.”

Dr S Radhika MD, PhD
Dr S Radhika MD, PhD
Professor, Deptt. Of Cytology & Gynaec Pathology, PGIMER, Chandigarh

“PGI Cytology Dept. has had a long association with DSS- Olympus Microscopy Division. They have provided excellent services- after sales service. The product is also of very good quality. We have had no problems with their products and services are of very good quality.”

Dr Nuzhat Husain
Dr Nuzhat Husain
RMLIMS, Lucknow

“Have been using Dako Reagents and Dako antibodies for a while. Services and products have been good and timely.”

Dr Minu Singh
Dr Minu Singh
Assistant Professor, PGIMER, Chandigarh

“MRC Holland MLPA products provided by DSS are of good quality, have never faced any quality issues with their product or shipping condition. They provide prompt response upon any query.”

Mr. Krishnani
Mr. Krishnani Professor, SGPGI, Lucknow

“My experience with DSS so far has been excellent for the last 30 years- sales and service experience. Microscope products are very useful and sturdy with high precision.”