Cancer Diagnostics
Cancer is a genetic disease. The uncontrolled proliferation and division of abnormal cells occur when mutated cell DNA inhibits the tumor suppressor gene function. Cancer arises when the cell DNA gets irreversibly damaged. Cancer can affect almost all parts of the human body. The possible factors for developing cancer can be environmental exposure, inheritance, and mutation of DNA that occurs in the cell division process. The cancer cells can also migrate from their original place to other parts through the blood or lymphatic system; this is known as Metastasis. There are many types of Cancer like Carcinoma that occurs in Epithelial cells, Sarcoma that occurs in connective tissue and Leukemia which occurs in Bone marrow. Early detection of cancer is very essential for better treatment and to control the severity.
DSS provides the solution for cancer diagnostics with a range of products like Entrogen Real-time PCR kits, Abbott Vysis FISH probes, MRC Holland MLPA kits, Dako antibodies, Olympus Microscopes, ASI software along with application support for the entire product range.
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IS quantitative, one-step RT-PCR for quantifying the IS ratios of BCR-ABL Major (M-BCR) p210 transcript in CML patient samples.
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Evaluates the molecular response up to 5 log reduction which is undetectable BCR-ABL1.
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JAK2 V617F Mutation Detection RT-PCR Kit for sensitive and specific detection of JAK2 (Janus Kinase 2) V617F allele in DNA samples with Beta Actin as an internal control.
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Discover the benefits of magnetic bead-based kits for nucleic acid purification. Purify high-quality nucleic acids from Biological Samples. Save time and increase consistency using the Magnetic Bead Nucleic Acid Extraction Kit
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Primary Antibodies are intended for use on tissue sections whereas control Reagents are well-suited as qualitative negative controls for the primary antibodies.
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Single-Tube, Multiplex Real-Time PCR Assay for sensitive and specific detection of Major (M-BCR) p210, Minor (m-BCR) p190, and Micro (μ-BCR) p230 BCR-ABL transcripts.
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BRCA Complete™ Expanded Panel is a complete next generation sequencing (NGS) solution for detecting clinically relevant BRCA1 and BRCA2 mutations along with extended coverage of CHEK2, PALB2, RAD51C and TP53.
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The Breast Cancer Comprehensive Panel analyzes 20 genes related to an expanded risk of hereditary breast cancer.
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SALSA® digital Multiplex Ligation-dependent Probe Amplification (digitalMLPA) is a multiplex PCR followed by Illumina sequencing-based amplicon quantification, for the detection of copy number variations (CNV) and specific point mutations.
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The UGT1A1 Genotyping Kit is a polymerase chain reaction (PCR)-based assay that uses allele-specific probes to identify the most common Irinotecan polymorphic variant.
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EntroGen’s GIST mutation screening panel is a real-time polymerase chain reaction (PCR)-based assay that uses allele-specific primers to identify the presence of somatic mutations in c-KIT and PDGFRA genes.
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EntroGen’s One-Step Detection kits provide reagents to detect and quantify the fusion gene transcripts listed below using total RNA isolated from blood or bone marrow.
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All kits require a real-time PCR instrument capable of detecting FAM and VIC fluorescent probes. Additionally, the Cell-Free EGFR Mutation Detection kit requires the capability to detect ROX and CY5 fluorescent probes. All reagents required for PCR amplification/detection, as well as validated reaction controls, are included. Columns and reagents for DNA or RNA isolation are not included.
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Entrogen's kits are polymerase chain reaction (PCR)-based assays that use allele-specific primers in a multiplex reaction to identify the presence of BRAF, NRAS, and c-Kit mutations. The assays work by amplifying mutant-specific sequences in samples that contain a mixture of mutant and wild-type DNA and rely on fluorescent probes for detection. Each reaction contains primer sets and probes for detection of the mutations, as well as an endogenous control gene.
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EntroGen’s Sample Quality Assessment kits provide reagents, positive controls, and standards (if applicable) to detect and quantify the amplifiable DNA extracted from patient samples or adaptor-indexed libraries intended for downstream qPCR and NGS assays, respectively.
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Thyroid Cancer Mutation Panel provides reagents for detection of point mutations in BRAF and RAS genes, as well as RET/PTC1, 3 and PAX8/PPARγ fusion genes variants.
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Hepatoma is called hepatocellular carcinoma (HCC) and hepatocarcinoma, it is the most common kind of primary liver malignancy.
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It is estimated that 10% of melanoma cases are attributed to hereditary predisposition.
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Neuropathology panels focus and evaluate all aspects of neurodegeneration.
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NGS THSP stands for NGS Targeted Hotspot Panel is supposed to detect the multiple clinically related hotspot mutations in 16 genes across several tumour types. Its comprehensive multi-gene panels identify hundreds of genes and detect thousands of variants, many of which have unknown factors.
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The PathVysion HER-2 DNA Probe Kit II (PathVysion Kit II) is designed to detect amplification of the HER-2/neu gene via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded human breast and gastric cancer tissue specimens.
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PD-L1 IHC 22C3 pharmDx Advancing Immunotherapy Options Cytotoxic T cells work to detect and eliminate infected cells and tumor cells from the body.
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PD-L1 IHC 28-8 pharmDx Advancing Immunotherapy Options Cytotoxic T cells work to detect and eliminate infected cells and tumor cells from the body.
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Entrogen's Mutation Analysis Kit requires a real-time thermal cycler capable of detecting FAM and VIC fluorescence signals. This test includes reagents required for the PCR amplification and signal detection, as well as validated reaction controls. Columns and reagents for DNA isolation are not included.
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