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SALSA® digitalMLPA Probemix D007 Acute Lymphoblastic Leukemia

MRC HOLLAND SALSA® digitalMLPA Probemix D007 Acute Lymphoblastic Leukemia in India

SALSA® digitalMLPA Probemix D007 Acute Lymphoblastic Leukemia
The SALSA digitalMLPA Probemix D007-A1 Acute lymphocytic leukemia is a research-use-only (RUO) assay for the detection of deletions, gains or amplifications in 52 specific target genes and three chromosomal regions (5q, iAMP21 and PAR1), which are related to acute lymphoblastic leukemia (ALL).
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Features & Benefits

  • 55 genes and regions targeted
  • High dynamic range for copy number alteration (CNA) detection
  • Only 20 ng of DNA input needed
  • Quick turnaround of 48-72 hours
  • Works on Illumina sequencing platform (all devices)

Product Details

D007 Acute Lymphoblastic Leukemia contains probes targeting:
  • Genes and regions included in the well-established SALSA® MLPA® probemixes for ALL:
    P335 ALL-IKZF1, P202 IKZF1-ERG, P327 iAMP21-ERG, and P329 CRLF2-CSF2RA-IL3RA.

  • B-cell differentiation and cell cycle control genes, T-ALL-associated aberrations, iAMP21, 5q terminal
    region and copy number aberrations of PAR1 region and other genes of emerging significance.

  • Karyotyping probes for subtelomeric, pericentromeric and middle regions of chromosomal arms
    to detect larger copy number alterations and ploidy status.

This assay is to be used with genomic DNA isolated from peripheral whole blood or bone marrow specimens and is not intended to be used with genomic DNA extracted from formalin-fixed paraffin-embedded or fresh-frozen tumour materials. CNAs detected with the D007 Acute lymphocytic leukemia Probemix should be confirmed with a different technique or with conventional MLPA probemixes when possible. particularly , CNAs detected by only one probe always require confirmation by another method. the bulk of defects in the genes included in this D007 Acute Lymphoblastic Leukemia Probemix are deletions, gains or amplifications, but point mutations can occur which can not be detected by digitalMLPA. it's therefore recommended to use this assay in combination with sequence analysis for the gene(s) of interest.
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