Product Details
D007 Acute Lymphoblastic Leukemia contains probes targeting:
This assay is to be used with genomic DNA isolated from peripheral whole blood or bone marrow specimens and is not intended to be used with genomic DNA extracted from formalin-fixed paraffin-embedded or fresh-frozen tumour materials. CNAs detected with the D007 Acute lymphocytic leukemia Probemix should be confirmed with a different technique or with conventional MLPA probemixes when possible. particularly , CNAs detected by only one probe always require confirmation by another method. the bulk of defects in the genes included in this D007 Acute Lymphoblastic Leukemia Probemix are deletions, gains or amplifications, but point mutations can occur which can not be detected by digitalMLPA. it's therefore recommended to use this assay in combination with sequence analysis for the gene(s) of interest.
- Genes and regions included in the well-established SALSA® MLPA® probemixes for ALL:
P335 ALL-IKZF1, P202 IKZF1-ERG, P327 iAMP21-ERG, and P329 CRLF2-CSF2RA-IL3RA.
- B-cell differentiation and cell cycle control genes, T-ALL-associated aberrations, iAMP21, 5q terminal
region and copy number aberrations of PAR1 region and other genes of emerging significance.
- Karyotyping probes for subtelomeric, pericentromeric and middle regions of chromosomal arms
to detect larger copy number alterations and ploidy status.
This assay is to be used with genomic DNA isolated from peripheral whole blood or bone marrow specimens and is not intended to be used with genomic DNA extracted from formalin-fixed paraffin-embedded or fresh-frozen tumour materials. CNAs detected with the D007 Acute lymphocytic leukemia Probemix should be confirmed with a different technique or with conventional MLPA probemixes when possible. particularly , CNAs detected by only one probe always require confirmation by another method. the bulk of defects in the genes included in this D007 Acute Lymphoblastic Leukemia Probemix are deletions, gains or amplifications, but point mutations can occur which can not be detected by digitalMLPA. it's therefore recommended to use this assay in combination with sequence analysis for the gene(s) of interest.