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Multiplex Ligation-Dependent Probe Amplification (MLPA)

Multiplex Ligation-Dependent Probe Amplification (MLPA)

 

MLPA is a semi-quantitative technique used to detect copy number variation associated with a disease. It was developed as a proprietary technology by MRC Holland for the detection of copy number variations which is considered the gold standard in this field and now being used all over the world to study tumours and hereditary disorders. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR based technology that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be processed contemporaneously with results being available within 24 hours. Over 350 assays targeting various genetic diseases are available.


DSS Imagetech Pvt Ltd is the sole authorised distributor for MRC Holland in India. We supply assays available with the MRC Holland portfolio. We also provide all possible technical support for our customers whenever needed. Customers are trained on assays and the software from our part.

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  1. MRC HOLLAND Digital MLPA Assay in India

    SALSA® digital Multiplex Ligation-dependent Probe Amplification (digitalMLPA) is a multiplex PCR followed by Illumina sequencing-based amplicon quantification, for the detection of copy number variations (CNV) and specific point mutations. 

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  2. MRC HOLLAND Methylation-Specific MLPA Assays in India

    Methylation-Specific (MS)-MLPA® is a variant of the MLPA technique, the gold standard in copy number determination. With MS-MLPA, it is possible to semi-quantitatively profile methylation for multiple targets simultaneously.

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  3. MRC HOLLAND MLPA Assays for  Lung Disorders in India

    MLPA Assays are useful in finding out those who have Lung Disorders

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  4. MRC HOLLAND MLPA Assays for Cardiovascular Disorders in India

    MLPA Assays are useful in finding out those who have cardiovascular diseases.

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  5. MRC HOLLAND MLPA Assays for Hereditary Blood Disorders in India

    MLPA Assays are useful in finding out those who have hereditary blood disorders.

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  6. MRC HOLLAND MLPA Assays for Intellectual Disability in India

    MLPA Assays are useful in finding out those who have Intellectual Disability

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  7. MRC HOLLAND MLPA Assays for Skeletal & Connective Tissue in India

    MLPA Assays are useful in finding out those who have Skeletal & Connective Tissue Disorders

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  8. MRC HOLLAND MLPA Assays for Tumour Profiling in India

    MLPA Assays are useful in tumor profiling for blood cancer, solid tumors as well as general tumor profiling

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  9. MRC HOLLAND SALSA® Melt Assays in India

    SALSA® Melt Assays are designed for the fast and reliable screening of a small number of targets in a large number of samples.

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