Multiplex Ligation-Dependent Probe Amplification (MLPA)
MLPA is a semi-quantitative technique used to detect copy number variation associated with a disease. It was developed as a proprietary technology by MRC Holland for the detection of copy number variations which is considered the gold standard in this field and now being used all over the world to study tumours and hereditary disorders. MLPA (Multiplex Ligation-dependant Probe Amplification (MLPA) is a multiplex PCR based technology that enables the copy number variation (CV) detection of up to 60 DNA sequences in a single reaction. 96 DNA samples can be processed contemporaneously with results being available within 24 hours. Over 350 assays targeting various genetic diseases are available.
DSS Imagetech Pvt Ltd is the sole authorised distributor for MRC Holland in India. We supply assays available with the MRC Holland portfolio. We also provide all possible technical support for our customers whenever needed. Customers are trained on assays and the software from our part.
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SALSA® digital Multiplex Ligation-dependent Probe Amplification (digitalMLPA) is a multiplex PCR followed by Illumina sequencing-based amplicon quantification, for the detection of copy number variations (CNV) and specific point mutations.
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Methylation-Specific (MS)-MLPA® is a variant of the MLPA technique, the gold standard in copy number determination. With MS-MLPA, it is possible to semi-quantitatively profile methylation for multiple targets simultaneously.
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MLPA Assays are useful in finding out those who have Lung Disorders
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MLPA can be used for the detection of deletions or duplications of certain genes involved in cardiovascular diseases.
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MLPA Assays are useful in finding out those who have hereditary blood disorders.
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MLPA Assays are useful in finding out those who have Skeletal & Connective Tissue Disorders
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MLPA Assays are useful in tumor profiling for blood cancer, solid tumors as well as general tumor profiling
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The SALSA digitalMLPAProbemix D006-A1 Multiple Myeloma is a research use only (RUO) assay for the detection of deletions, gains or amplifications of genes and chromosomal regions mentioned in Table 2 that are recurrently altered in multiple myeloma, such as 1p, 1q, 13q and 17p, as well as for the detection of BRAF p.V600E point mutation.
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The SALSA digitalMLPA Probemix D007-A1 Acute lymphocytic leukemia is a research-use-only (RUO) assay for the detection of deletions, gains or amplifications in 52 specific target genes and three chromosomal regions (5q, iAMP21 and PAR1), which are related to acute lymphoblastic leukemia (ALL).
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SALSA® Melt Assays are designed for the fast and reliable screening of a small number of targets in a large number of samples.
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